Neutrophil Extracellular Traps Promote Aberrant Macrophages Activation in Behçet’s Disease

• Published in: Frontiers in immunology Vol. 11; p. 590622
• Main Authors: Li, Lu, Yu, Xin, Liu, Jinjing, Wang, Zhimian, Li, Chaoran, Shi, Jing, Sun, Luxi, Liu, Yi, Zhang, Fengchun, Chen, Hua, Zheng, Wenjie
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.02.2021
• Subjects: Behçet’s disease; histone H4; Immunology; macrophages; neutrophil extracellular traps; oxidized DNA; oxidized DNA; macrophages; neutrophil extracellular traps; Behçet’s disease; histone H4

Neutrophil extracellular traps (NETs) are upregulated and promote thrombosis in Behçet’s disease (BD). However, whether NETs promote autoinflammation in BD remains unclear. This study aimed to investigate the potential role of NETs in promoting macrophage activation in BD. Firstly, we quantified NET...