Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 43; no. 10; pp. 2134 - 2145
• Main Authors: Carboni, Lucia, Marchetti, Luca, Lauria, Mario, Gass, Peter, Vollmayr, Barbara, Redfern, Amanda, Jones, Lesley, Razzoli, Maria, Malki, Karim, Begni, Veronica, Riva, Marco A., Domenici, Enrico, Caberlotto, Laura, Mathé, Aleksander A.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.09.2018; Springer International Publishing
• Subjects: Animal models; Animals; Brain Chemistry - genetics; Computational Biology; Depressive Disorder, Major - genetics; Depressive Disorder, Major - physiopathology; ErbB protein; Fibroblast growth factors; Gene expression; Gene Expression Profiling; Gene Expression Regulation - genetics; Helplessness, Learned; Hippocampal plasticity; Hippocampus; Hippocampus - drug effects; Hippocampus - physiology; Humans; Immune response; Inflammation; Insulin; Insulin-like growth factors; Intercellular Signaling Peptides and Proteins - genetics; Learned helplessness; Leptin; Male; Mental depression; Metabolic disorders; Neuroplasticity; Rats; Rodents; Scavenger Receptors, Class A - genetics; Signal transduction; Signal Transduction - genetics; Species Specificity; Transcription; Transcriptome - genetics; Vascular endothelial growth factor

An enhanced understanding of the pathophysiology of depression would facilitate the discovery of new efficacious medications. To this end, we examined hippocampal transcriptional changes in rat models of disease and in humans to identify common disease signatures by using a new algorithm for signatu...