Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation

• Published in: PLoS neglected tropical diseases Vol. 7; no. 7; p. e2307
• Main Authors: Thivierge, Karine, Cotton, Sophie, Schaefer, Deborah A, Riggs, Michael W, To, Joyce, Lund, Maria E, Robinson, Mark W, Dalton, John P, Donnelly, Sheila M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2013; Public Library of Science (PLoS)
• Subjects: Animals; Anti-Bacterial Agents - metabolism; Antimicrobial Cationic Peptides - immunology; Antimicrobial Cationic Peptides - metabolism; Bacteria - drug effects; Biology; Cattle; Cells, Cultured; Cytokines; Cytotoxins - metabolism; Erythrocytes - drug effects; Fasciola hepatica; Fasciola hepatica - immunology; Helminth Proteins - immunology; Helminth Proteins - metabolism; Host-Pathogen Interactions; Humans; Immune system; Immunologic Factors - immunology; Immunologic Factors - metabolism; Macrophage Activation - drug effects; Macrophages - drug effects; Macrophages - immunology; Medical research; Medicine; Mice; Mice, Inbred BALB C; Parasites; Schistosoma mansoni; Schistosoma mansoni - immunology; Wound healing; Immunologic Factors; Schistosoma mansoni; Antimicrobial Cationic Peptides; Humans; Cells, Cultured; Erythrocytes; Macrophages; Macrophage Activation; Host-Pathogen Interactions; Cytotoxins; Fasciola hepatica; Anti-Bacterial Agents; Animals; Helminth Proteins; Cattle; Bacteria; Mice; Mice, Inbred BALB C

Host defence peptides (HDPs) are expressed throughout the animal and plant kingdoms. They have multifunctional roles in the defence against infectious agents of mammals, possessing both bactericidal and immune-modulatory activities. We have identified a novel family of molecules secreted by helminth...