Stem Cell-Based Clinical Trials for Diabetes Mellitus

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 631463
• Main Authors: de Klerk, Eleonora, Hebrok, Matthias
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.02.2021
• Subjects: clinical trial (CT); Clinical Trials as Topic; Diabetes Mellitus - therapy; encapsulation; Endocrinology; Humans; Islets of Langerhans Transplantation - methods; Stem Cell Transplantation - methods; stem cells; transplantation; type 1 diabetes (T1D); type 2 diabetes (T2D); encapsulation; stem cells; clinical trial (CT); islets; transplantation; type 2 diabetes (T2D); type 1 diabetes (T1D)

Since its introduction more than twenty years ago, intraportal allogeneic cadaveric islet transplantation has been shown to be a promising therapy for patients with Type I Diabetes (T1D). Despite its positive outcome, the impact of islet transplantation has been limited due to a number of confoundin...