Development of an Inflammatory CD14+ Dendritic Cell Subset in Humanized Mice

• Published in: Frontiers in immunology Vol. 12; p. 643040
• Main Authors: Iwabuchi, Ryutaro, Ide, Keigo, Terahara, Kazutaka, Wagatsuma, Ryota, Iwaki, Rieko, Matsunaga, Hiroko, Tsunetsugu-Yokota, Yasuko, Takeyama, Haruko, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.03.2021
• Subjects: CD14; DC3; dendritic cell; humanized mice; Immunology; inflammatory response; S100A8; DC3; humanized mice; inflammatory response; CD14; S100A9; S100A8; dendritic cell

Humanized mouse models are attractive experimental models for analyzing the development and functions of human dendritic cells (DCs) in vivo . Although various types of DC subsets, including DC type 3 (DC3s), have been identified in humans, it remains unclear whether humanized mice can reproduce het...