Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 2; pp. 548 - 553
• Main Authors: Pu, Juan, Wang, Shuoguo, Yin, Yanbo, Zhang, Guozhong, Carter, Robert A., Wang, Jinliang, Xu, Guanlong, Sun, Honglei, Wang, Min, Wen, Chu, Wei, Yandi, Wang, Dongdong, Zhu, Baoli, Lemmon, Gordon, Jiao, Yuannian, Duan, Susu, Wang, Qian, Du, Qian, Sun, Meng, Bao, Jinnan, Sun, Yipeng, Zhao, Jixun, Zhang, Hui, Wu, Gang, Liu, Jinhua, Webster, Robert G.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.01.2015; National Acad Sciences
• Subjects: Adaptability; Animals; Antigenic Variation - genetics; Antigens, Viral - genetics; avian influenza; Biological Sciences; Chickens; Chickens - virology; China; China - epidemiology; Evolution; Evolution, Molecular; farms; genes; Genes, Viral; Genetic Drift; Genotype; Genotype & phenotype; Genotypes; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; human diseases; Humans; Influenza; Influenza A virus; Influenza A Virus, H7N9 Subtype - genetics; Influenza A Virus, H7N9 Subtype - immunology; Influenza A Virus, H7N9 Subtype - pathogenicity; Influenza A Virus, H9N2 Subtype - genetics; Influenza A Virus, H9N2 Subtype - immunology; Influenza A Virus, H9N2 Subtype - pathogenicity; Influenza in Birds - epidemiology; Influenza in Birds - virology; Influenza virus; Influenza, Human - epidemiology; Influenza, Human - virology; pandemic; Pandemics; Phylogeny; Poultry; Reassortant Viruses - genetics; Reassortant Viruses - immunology; Reassortant Viruses - pathogenicity; Retrospective Studies; viruses; China; China, People's Rep; H7N9; H9N2; infectivity; chicken influenza virus; genotype

The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant’s internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the g...