Lactate dehydrogenase activity drives hair follicle stem cell activation

• Published in: Nature cell biology Vol. 19; no. 9; pp. 1017 - 1026
• Main Authors: Flores, Aimee, Schell, John, Krall, Abigail S., Jelinek, David, Miranda, Matilde, Grigorian, Melina, Braas, Daniel, White, Andrew C., Zhou, Jessica L., Graham, Nicholas A., Graeber, Thomas, Seth, Pankaj, Evseenko, Denis, Coller, Hilary A., Rutter, Jared, Christofk, Heather R., Lowry, William E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2017; Nature Publishing Group
• Subjects: 13; 42; 42/100; 631/443/319; 631/532/2438; 631/532/2443; 631/80/642/333; 64; 64/60; 82; 82/51; 82/58; Acrylates - pharmacology; Animals; Anion Transport Proteins - antagonists & inhibitors; Anion Transport Proteins - genetics; Anion Transport Proteins - metabolism; Cancer Research; Cell activation; Cell Biology; Cell metabolism; Cell Proliferation - drug effects; Cellular Senescence - drug effects; Clonal deletion; Dehydrogenase; Dehydrogenases; Developmental Biology; Epidermis; Female; Genetic aspects; Genotype; Glycolysis; Glycolysis - drug effects; Hair; Hair Follicle - cytology; Hair Follicle - drug effects; Hair Follicle - enzymology; Hair follicles; Health aspects; Isoenzymes - deficiency; Isoenzymes - genetics; Isoenzymes - metabolism; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - deficiency; L-Lactate Dehydrogenase - genetics; L-Lactate Dehydrogenase - metabolism; Lactate dehydrogenase; Lactate Dehydrogenase 5; Lactic acid; Lactic Acid - metabolism; Life Sciences; Male; Metabolism; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins - antagonists & inhibitors; Mitochondrial Membrane Transport Proteins - genetics; Mitochondrial Membrane Transport Proteins - metabolism; Monocarboxylic Acid Transporters; Myc protein; Phenotype; Proto-Oncogene Proteins c-myc - metabolism; Pyruvic acid; Signal Transduction; Stem Cells; Stem Cells - drug effects; Stem Cells - enzymology; Time Factors

Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glyc...