Endothelin-1 Promotes Osteosarcoma Cell Invasion and Survival against Cisplatin-induced Apoptosis

• Published in: Clinical orthopaedics and related research Vol. 469; no. 11; pp. 3190 - 3199
• Main Authors: Zhao, Yuanting, Liao, Qiande, Zhu, Yong, Long, Haitao
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.11.2011; Springer; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adolescent; Adult; Antagonists; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Basic Research; Biological and medical sciences; Bone matrix; Bone Neoplasms - drug therapy; Bone Neoplasms - genetics; Bone Neoplasms - metabolism; Bone remodelling; Cell migration; Cell number; Cell proliferation; Cell survival; Cell Survival - drug effects; Child; Child, Preschool; Cisplatin; Cisplatin - pharmacology; Conservative Orthopedics; Diseases of the osteoarticular system; Drug Screening Assays, Antitumor; Endothelin 1; Endothelin A Receptor Antagonists; Endothelin ETB receptors; Endothelin-1 - genetics; Endothelin-1 - metabolism; Enzyme-linked immunosorbent assay; Female; Gene Expression; Humans; Male; Malignancy; Medical sciences; Medicine; Medicine & Public Health; Metastases; Middle Aged; mRNA; Neoplasm Invasiveness; Neoplasm Staging; Orthopedics; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - genetics; Osteosarcoma - metabolism; Osteosarcoma cells; Polymerase chain reaction; Receptor, Endothelin A - genetics; Receptor, Endothelin A - metabolism; RNA, Messenger - metabolism; RNA, Neoplasm - analysis; Sports Medicine; Surgery; Surgical Orthopedics; Tumor; Tumor Cells, Cultured; Tumors of striated muscle and skeleton; Young Adult; Cell Invasion Ability; BQ123; Apoptotic Stress; Cell Death Rate; Antineoplastic agent; Prognosis; Sarcoma; Diseases of the osteoarticular system; Endothelin 1; Malignant tumor; Survival; Cisplatin; Invasion; Alkylating agent; Osteosarcoma; Orthopedics; Bone; Cancer; Platinum II Complexes; Apoptosis

Background Endothelin-1 (ET-1) participates in a wide range of cancer-relevant processes including cell proliferation, inhibition of apoptosis, matrix remodeling, bone deposition, and metastases. Although ET-1 reportedly promotes osteosarcoma (OS) cell invasion, suggesting an important role of ET-1...