Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet

• Published in: Biochimica et biophysica acta Vol. 1830; no. 1; pp. 2226 - 2232
• Main Authors: Castro, María C., Massa, María L., Schinella, Guillermo, Gagliardino, Juan J., Francini, Flavio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2013
• Subjects: Animals; antioxidant activity; antioxidants; Antioxidants - metabolism; Antioxidants - pharmacology; blood glucose; catalase; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; diet; Diet - adverse effects; fasting; fatty-acid synthase; Fructose; Fructose - adverse effects; Fructose - pharmacology; gene expression; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; genes; glucokinase; glucose tolerance; glucose tolerance tests; glutathione; glycerol-3-phosphate acyltransferase; Glycoxidative stress; hyperinsulinemia; hypertriglyceridemia; Insulin Resistance; Ion Channels - genetics; Ion Channels - metabolism; lipoic acid; liver; Liver - metabolism; Liver - pathology; Liver uncoupling protein 2; Male; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; noninsulin-dependent diabetes mellitus; obesity; Obesity - drug therapy; Obesity - genetics; Obesity - metabolism; oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - genetics; Oxidoreductases - biosynthesis; Oxidoreductases - genetics; PPAR delta - genetics; PPAR delta - metabolism; PPAR gamma - genetics; PPAR gamma - metabolism; PPAR regulation; Pre-diabetes; protein synthesis; R/S-α-lipoic acid; Rats; Rats, Wistar; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; superoxide dismutase; Sweetening Agents - adverse effects; Sweetening Agents - pharmacology; Thioctic Acid - pharmacology; Uncoupling Protein 2; T2DM; UCP; F; Liver uncoupling protein 2; R/S-α-lipoic acid; SOD2; GPAT-1; Fructose; AUC; SOD1; HOMA-IR; Glycoxidative stress; LA; ROS; Pre-diabetes; PPAR regulation; FAS; FPG; OGTT; GSH; FPI; ABTS

To evaluate whether co-administration of R/S-α-lipoic acid can prevent the development of oxidative stress and metabolic changes induced by a fructose-rich diet (F). We assessed glycemia in the fasting state and during an oral glucose tolerance test, triglyceridemia and insulinemia in rats fed with...