AMPK signaling and its targeting in cancer progression and treatment

• Published in: Seminars in cancer biology Vol. 85; pp. 52 - 68
• Main Authors: Hsu, Che-Chia, Peng, Danni, Cai, Zhen, Lin, Hui-Kuan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2022
• Subjects: AMP-Activated Protein Kinases - metabolism; AMPK; Cancer; Energy Metabolism; Epigenesis, Genetic; Glucose deprivation; Humans; Metabolism; Mitocondria; Neoplasms - drug therapy; Neoplasms - metabolism; Phosphorylation; Signal Transduction; AMPK; Phosphorylation; Glucose deprivation; Metabolism; Cancer; Mitocondria

The intrinsic mechanisms sensing the imbalance of energy in cells are pivotal for cell survival under various environmental insults. AMP-activated protein kinase (AMPK) serves as a central guardian maintaining energy homeostasis by orchestrating diverse cellular processes, such as lipogenesis, glyco...