Construction of Vero cell-adapted rabies vaccine strain by five amino acid substitutions in HEP-Flury strain

• Published in: Scientific Reports Vol. 14; no. 1; pp. 12559 - 16
• Main Authors: Harada, Michiko, Matsuu, Aya, Park, Eun-Sil, Inoue, Yusuke, Uda, Akihiko, Kaku, Yoshihiro, Okutani, Akiko, Posadas-Herrera, Guillermo, Ishijima, Keita, Inoue, Satoshi, Maeda, Ken
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 31.05.2024; Nature Publishing Group UK; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/590; 631/326/596; Amino Acid Substitution; Amino acids; Animals; Antigenicity; Antiretroviral drugs; Bats; Chlorocebus aethiops; Disease prevention; Embryos; Genetics; Genome, Viral; Glycoproteins; Humanities and Social Sciences; Humans; Lyssavirus; Medicine; multidisciplinary; Mutation; Neurological diseases; Prophylaxis; Q; R; Rabies; Rabies - prevention & control; Rabies - virology; Rabies Vaccines - genetics; Rabies Vaccines - immunology; Rabies virus - genetics; Rabies virus - immunology; Science; Science (multidisciplinary); Stomatitis; Strains (organisms); Vaccines; Vero Cells; Vesicular stomatitis; Virulence; Viruses

Rabies virus (RABV) causes fatal neurological disease. Pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) using inactivated-virus vaccines are the most effective measures to prevent rabies. In Japan, HEP-Flury, the viral strain, used as a human rabies vaccine, has historically been...