The effects of chromium and copper supplementation on mitogen‐stimulated T cell proliferation in hypercholesterolaemic postmenopausal women
The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 × 2 factorial research design was used and 40 subjects were supplemented with 0·394 g lactose, 200 μg Cr, 3·0 mg Cu, or 200 μg Cr and 3·0 m...
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| Published in | Clinical and experimental immunology Vol. 127; no. 3; pp. 463 - 469 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Science, Ltd
01.03.2002
Blackwell Blackwell Science Inc |
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| Abstract | The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 × 2 factorial research design was used and 40 subjects were supplemented with 0·394 g lactose, 200 μg Cr, 3·0 mg Cu, or 200 μg Cr and 3·0 mg Cu/d for 12 weeks. A significant interactive effect of Cr and Cu supplementation on lymphocyte proliferation was observed with ConA 50 μg/ml stimulation. After 12 weeks of supplementation, ConA‐stimulated (50 μg/ml) lymphocyte proliferation was significantly lower when Cu was added to the Cr supplementation group. Moreover, ConA‐stimulated (100 μg/ml) lymphocyte proliferation was significantly lower in the Cu supplementation group compared to the Cr supplementation group after 12 weeks of supplementation. These results suggest that Cu blocks enhancement of lymphocyte proliferation by Cr supplementation and that Cu supplementation has potential suppressive effects on the immune function in these subjects. |
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| AbstractList | The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 x 2 factorial research design was used and 40 subjects were supplemented with 0.394 g lactose, 200 microg Cr, 3.0 mg Cu, or 200 microg Cr and 3.0 mg Cu/d for 12 weeks. A significant interactive effect of Cr and Cu supplementation on lymphocyte proliferation was observed with ConA 50 microg/ml stimulation. After 12 weeks of supplementation, ConA-stimulated (50 microg/ml) lymphocyte proliferation was significantly lower when Cu was added to the Cr supplementation group. Moreover, ConA-stimulated (100 microg/ml) lymphocyte proliferation was significantly lower in the Cu supplementation group compared to the Cr supplementation group after 12 weeks of supplementation. These results suggest that Cu blocks enhancement of lymphocyte proliferation by Cr supplementation and that Cu supplementation has potential suppressive effects on the immune function in these subjects. The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 × 2 factorial research design was used and 40 subjects were supplemented with 0·394 g lactose, 200 μg Cr, 3·0 mg Cu, or 200 μg Cr and 3·0 mg Cu/d for 12 weeks. A significant interactive effect of Cr and Cu supplementation on lymphocyte proliferation was observed with ConA 50 μg/ml stimulation. After 12 weeks of supplementation, ConA-stimulated (50 μg/ml) lymphocyte proliferation was significantly lower when Cu was added to the Cr supplementation group. Moreover, ConA-stimulated (100 μg/ml) lymphocyte proliferation was significantly lower in the Cu supplementation group compared to the Cr supplementation group after 12 weeks of supplementation. These results suggest that Cu blocks enhancement of lymphocyte proliferation by Cr supplementation and that Cu supplementation has potential suppressive effects on the immune function in these subjects. The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 x 2 factorial research design was used and 40 subjects were supplemented with 0.394 g lactose, 200 microg Cr, 3.0 mg Cu, or 200 microg Cr and 3.0 mg Cu/d for 12 weeks. A significant interactive effect of Cr and Cu supplementation on lymphocyte proliferation was observed with ConA 50 microg/ml stimulation. After 12 weeks of supplementation, ConA-stimulated (50 microg/ml) lymphocyte proliferation was significantly lower when Cu was added to the Cr supplementation group. Moreover, ConA-stimulated (100 microg/ml) lymphocyte proliferation was significantly lower in the Cu supplementation group compared to the Cr supplementation group after 12 weeks of supplementation. These results suggest that Cu blocks enhancement of lymphocyte proliferation by Cr supplementation and that Cu supplementation has potential suppressive effects on the immune function in these subjects.The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 x 2 factorial research design was used and 40 subjects were supplemented with 0.394 g lactose, 200 microg Cr, 3.0 mg Cu, or 200 microg Cr and 3.0 mg Cu/d for 12 weeks. A significant interactive effect of Cr and Cu supplementation on lymphocyte proliferation was observed with ConA 50 microg/ml stimulation. After 12 weeks of supplementation, ConA-stimulated (50 microg/ml) lymphocyte proliferation was significantly lower when Cu was added to the Cr supplementation group. Moreover, ConA-stimulated (100 microg/ml) lymphocyte proliferation was significantly lower in the Cu supplementation group compared to the Cr supplementation group after 12 weeks of supplementation. These results suggest that Cu blocks enhancement of lymphocyte proliferation by Cr supplementation and that Cu supplementation has potential suppressive effects on the immune function in these subjects. The purpose of this study was to analyse effects of chromium and/or copper supplementation on immune function in hypercholesterolaemic postmenopausal women. A 2 x 2 factorial research design was used and 40 subjects were supplemented with 0.394 g lactose, 200 mu g Cr, 3.0 mg Cu, or 200 mu g Cr and 3.0 mg Cu/d for 12 weeks. A significant interactive effect of Cr and Cu supplementation on lymphocyte proliferation was observed with ConA 50 mu g/ml stimulation. After 12 weeks of supplementation, ConA-stimulated (50 mu g/ml) lymphocyte proliferation was significantly lower when Cu was added to the Cr supplementation group. Moreover, ConA-stimulated (100 mu g/ml) lymphocyte proliferation was significantly lower in the Cu supplementation group compared to the Cr supplementation group after 12 weeks of supplementation. These results suggest that Cu blocks enhancement of lymphocyte proliferation by Cr supplementation and that Cu supplementation has potential suppressive effects on the immune function in these subjects. |
| Author | Burnham, K. Rhee, Y. S. Hermann, J. R. Arquitt, A. B. Stoecker, B. J. |
| Author_xml | – sequence: 1 givenname: Y. S. surname: Rhee fullname: Rhee, Y. S. – sequence: 2 givenname: J. R. surname: Hermann fullname: Hermann, J. R. – sequence: 3 givenname: K. surname: Burnham fullname: Burnham, K. – sequence: 4 givenname: A. B. surname: Arquitt fullname: Arquitt, A. B. – sequence: 5 givenname: B. J. surname: Stoecker fullname: Stoecker, B. J. |
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| Keywords | Human Cell proliferation Immune response Immunomodulation Menopause Biological activity Feeding T-Lymphocyte Chromium Female Mitogen Supplementation Copper |
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| SubjectTerms | Adult Aged Basophils - drug effects Biological and medical sciences Cells, Cultured chromium Chromium - administration & dosage Chromium - pharmacology Clinical Studies copper Copper - administration & dosage Copper - pharmacology Dietary Supplements Double-Blind Method Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypercholesterolemia - diagnosis Hypercholesterolemia - immunology Immunobiology lymphocyte Lymphocyte Activation - drug effects Middle Aged mitogen Mitogens - pharmacology Modulation of the immune response (stimulation, suppression) postmenopausal women Postmenopause T-Lymphocytes - drug effects T-Lymphocytes - immunology |
| Title | The effects of chromium and copper supplementation on mitogen‐stimulated T cell proliferation in hypercholesterolaemic postmenopausal women |
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