Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

• Published in: The FASEB journal Vol. 29; no. 4; p. 1395
• Main Authors: Reigstad, Christopher S, Salmonson, Charles E, Rainey, 3rd, John F, Szurszewski, Joseph H, Linden, David R, Sonnenburg, Justin L, Farrugia, Gianrico, Kashyap, Purna C
• Format: Journal Article
• Language: English
• Published: United States 01.04.2015
• Subjects: Animals; Cell Count; Cell Line; Chromogranin A - genetics; Colon - cytology; Colon - metabolism; Colon - microbiology; Digestive System - microbiology; Enterochromaffin Cells - cytology; Enterochromaffin Cells - metabolism; Enterochromaffin Cells - microbiology; Fatty Acids, Volatile - metabolism; Female; Gastrointestinal Motility; Germ-Free Life; Humans; Male; Mice; Microbiota; RNA, Messenger - genetics; RNA, Messenger - metabolism; Serotonin - biosynthesis; Signal Transduction; Tryptophan Hydroxylase - genetics; Tryptophan Hydroxylase - metabolism; gnotobiotic; 5-hydroxytryptamine; microbiome; host-microbe interaction; gut motility

Gut microbiota alterations have been described in several diseases with altered gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut microbiome in modulating GI function. Serotonin [5-hydroxytryptamine (5-HT)] is a key regulator of GI motility and secretion. To d...