Swelling and fibronectin accumulation in articular cartilage explants after cyclical impact

• Published in: Journal of orthopaedic research Vol. 14; no. 3; p. 417
• Main Authors: Farquhar, T, Xia, Y, Mann, K, Bertram, J, Burton-Wurster, N, Jelinski, L, Lust, G
• Format: Journal Article
• Language: English
• Published: United States 01.05.1996
• Subjects: Animals; Cartilage, Articular - chemistry; Cartilage, Articular - cytology; Cartilage, Articular - injuries; Dogs; Edema; Fibronectins - metabolism; Organ Culture Techniques; Osteoarthritis - physiopathology; Sodium Chloride - metabolism; Sulfates - metabolism; Water - metabolism

The objective of this study was to determine if repeated impact could damage living cartilage and lead to osteoarthritis-like changes in its biology. Canine cartilage explants were subjected to impacts of as much as 50 MPa once every 5 seconds for 30 minutes. On each impact cycle, the loading rate w...