Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops

• Published in: Molecular nutrition & food research Vol. 58; no. 2; pp. 248 - 255
• Main Authors: Legette, LeeCole, Karnpracha, Chanida, Reed, Ralph L, Choi, Jaewoo, Bobe, Gerd, Christensen, J. Mark, Rodriguez‐Proteau, Rosita, Purnell, Jonathan Q, Stevens, Jan F
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.02.2014; Wiley
• Subjects: absorption; administration & dosage; Administration, Oral; Adult; bioactive properties; Biological and medical sciences; blood; chemistry; Chromatography, Liquid; Dose-Response Relationship, Drug; Feeding. Feeding behavior; Female; Flavanones; Flavanones - administration & dosage; Flavanones - pharmacokinetics; Flavonoids; Flavonoids - administration & dosage; Flavonoids - blood; Flavonoids - pharmacokinetics; Fundamental and applied biological sciences. Psychology; Half-Life; Hops; Human metabolism; Humans; Humulus; Humulus - chemistry; Hypoglycemic Agents; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - pharmacokinetics; ingestion; Male; men; metabolites; Pharmacokinetics; Propiophenones; Propiophenones - administration & dosage; Propiophenones - blood; Propiophenones - pharmacokinetics; Tandem Mass Spectrometry; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Xanthohumol; Xanthones; Xanthones - administration & dosage; Xanthones - pharmacokinetics; Human; Nutrition; Xanthohumol; Hops; Antioxidant; Metabolism; Flavonoid; Micronutrient; Polyphenol; Flavonoids; Plant origin; Phenols; Proanthocyanidin; Pharmacokinetics; Human metabolism

SCOPE: Xanthohumol (XN) is a bioactive prenylflavonoid from hops. A single‐dose pharmacokinetic (PK) study was conducted in men (n = 24) and women (n = 24) to determine dose–concentration relationships. METHODS AND RESULTS: Subjects received a single oral dose of 20, 60, or 180 mg XN. Blood was coll...