Dual‐Enhanced SERS Satellite Immuno‐Nanocomplex for Multiple PSA‐Mediated PHI Assay Toward Clinical Prostate Cancer Screening

• Published in: Advanced science Vol. 12; no. 5; pp. e2411747 - n/a
• Main Authors: Chen, Dong, Ma, Yilin, Yang, Annan, Hu, Liping, Zhou, Hanlin, Xu, Jun, Chen, Shanze, Nie, Dingmeng, Feng, Weifeng, Cai, Huaihong, Cong, Yanguang, Pi, Jiang, Rao, Lang, Huang, Xueqin, Sun, Pinghua, Zhou, Haibo
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.02.2025; John Wiley and Sons Inc; Wiley
• Subjects: Atoms & subatomic particles; Biomarkers; Biopsy; Early Detection of Cancer - methods; Gold - chemistry; Humans; Immunoassay; Immunoassay - methods; intra‐nanogap particles; Male; Medical screening; Metal Nanoparticles - chemistry; PCa screening; Prostate cancer; prostate health index; prostate specific antigen; Prostate-Specific Antigen - analysis; Prostate-Specific Antigen - blood; Prostatic Neoplasms - diagnosis; Spectrum Analysis, Raman - methods; surface‐enhanced raman scattering; surface‐enhanced raman scattering; prostate specific antigen; prostate health index; intra‐nanogap particles; PCa screening

Prostate specific antigen (PSA) is widely used in liquid biopsy of prostate cancer (PCa) but still faces challenges due to the poor specificity. Herein, this study reports a double‐SERS satellite immunoassay, made of an Au–Ag dealloyed intra‐nanogap nanoflower (Au–Ag DINF) with strong SERS signals a...