Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina

• Published in: Microbiology (Society for General Microbiology) Vol. 145; no. 8; pp. 1919 - 1926
• Main Authors: Strobel, G.A, Miller, V, Martinez-Miller, C, Condron, M.M, Teplow, D.B, Hess, W.M
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.08.1999; Society for General Microbiology
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; antifungal properties; Ascomycota - growth & development; Ascomycota - isolation & purification; Ascomycota - metabolism; Biological and medical sciences; Botrytis cinerea; Candida albicans; Chromatography, Thin Layer; Cryptosporiopsis quercina; Culture Media; endophytes; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Microbial Sensitivity Tests; Mitosporic Fungi - drug effects; pathogens; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - pharmacology; Pharmacology. Drug treatments; plant pathogenic fungi; Sclerotinia sclerotiorum; Trichophyton mentagrophytes; Trichophyton rubrum; Fungi; Antifungal agent; Molecular structure; Minimum inhibitory concentration; Endophyte; Fungi Imperfecti; In vitro; Biological activity; Lipopeptide; Thallophyta
• ISSN: 1350-0872; 1465-2080
• DOI: 10.1099/13500872-145-8-1919

A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known antimycotics, the echinocandins and pneumocandins, which are produced by such fungi as Zalerion arboricola, Pezicula spp. and Aspergillus spp. Cryptocandin has minimal inhibitory concentration values of 0.03-0.07 microgram/ml against isolates of Candida albicans, Trichophyton mentagrophytes and Trichophyton rubrum. Cryptocandin is also active against a number of plant-pathogenic fungi including Sclerotinia sclerotiorum and Botrytis cinerea.