Causes and Consequences of Coronavirus Spike Protein Variability

• Published in: Viruses Vol. 16; no. 2; p. 177
• Main Authors: Zech, Fabian, Jung, Christoph, Jacob, Timo, Kirchhoff, Frank
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.01.2024; MDPI
• Subjects: Animals; Causes of; Coronavirus 229E, Human; Coronaviruses; COVID-19; COVID-19 infection; COVID-19 vaccines; Disease resistance; Disease transmission; human population; Humans; immune evasion; Infections; Infectivity; manifestation; Middle East respiratory syndrome; Mutation; Pandemics; Pathogenicity; pathogens; Peptides; Physiological aspects; Proteins; Public health; Review; RNA; RNA viruses; Sarbecoviruses; SARS-CoV-2; Severe acute respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2; Spike; Spike Glycoprotein, Coronavirus - genetics; Spike protein; therapeutics; Viral proteins; Virus research; Viruses; Zoonoses; Germany; Spike; mutation; SARS-CoV-2; manifestation; immune evasion; zoonoses; Sarbecoviruses

Coronaviruses are a large family of enveloped RNA viruses found in numerous animal species. They are well known for their ability to cross species barriers and have been transmitted from bats or intermediate hosts to humans on several occasions. Four of the seven human coronaviruses (hCoVs) are resp...