Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models

• Published in: Biochimica et biophysica acta Vol. 1862; no. 3; pp. 532 - 546
• Main Authors: Bottini, Massimo, Mebarek, Saida, Anderson, Karen L., Strzelecka-Kiliszek, Agnieszka, Bozycki, Lukasz, Simão, Ana Maria Sper, Bolean, Maytê, Ciancaglini, Pietro, Pikula, Joanna Bandorowicz, Pikula, Slawomir, Magne, David, Volkmann, Niels, Hanein, Dorit, Millán, José Luis, Buchet, Rene
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2018; Elsevier
• Subjects: Animals; Apatites - metabolism; Atomic force microscopy; biogenesis; Biomimetic Materials; biomimetics; bone formation; Calcification, Physiologic - physiology; Calcinosis - physiopathology; Cellular Biology; chondrocytes; Chondrocytes - pathology; Chondrocytes - ultrastructure; collagen; Collagen - metabolism; Electron microscopy; Extracellular Matrix - metabolism; Extracellular Vesicles - physiology; Humans; Hypertrophy; Life Sciences; lipid composition; Lipid raft; lipids; Matrix vesicles; Membrane Microdomains - physiology; Mineralization; minerals; Minerals - metabolism; Models, Biological; myocytes; Organelle Biogenesis; osteoblasts; Osteoblasts - ultrastructure; Proteolipids; Proteoliposomes; proteomics; smooth muscle; Specimen Handling; transmission electron microscopy; Vascular Calcification - physiopathology; FFA; GPI; Atomic force microscopy; PS; OPN; TNAP; SMPD3; Mineralization; CHOL; DOPC; EXs; VSMCs; Lipid raft; PiT-1; EM; Electron microscopy; BCP; DPPS; RA; MAG; PHOSPHO1; NC; Cryo-EM; ND; ANK; CPPD; PMVs; TSG101; E; AnxA1, AnxA2, AnxA4, AnxA5, AnxA6, AnxA7; AFM; IL-1beta; SD; OA; miRNA; SM; TLR; WT; ENPP1 (or NPP1); DPPC; IIAC; ACVs; EVs; BMP; Matrix vesicles; IVs; MMPs; PPi; DAG; MVs; ACP; ECM; OMFs; Proteoliposomes; ABs; PC; UCC; PE; PI; TAG; OCP; TEM

Matrix vesicles (MVs) are released from hypertrophic chondrocytes and from mature osteoblasts, the cells responsible for endochondral and membranous ossification. Under pathological conditions, they can also be released from cells of non-skeletal tissues such as vascular smooth muscle cells. MVs are...