A2A Adenosine Receptor Protects Tumors from Antitumor T Cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 35; pp. 13132 - 13137
• Main Authors: Ohta, Akio, Gorelik, Elieser, Prasad, Simon J., Ronchese, Franca, Lukashev, Dmitriy, Wong, Michael K. K., Huang, Xiaojun, Caldwell, Sheila, Liu, Kebin, Smith, Patrick, Chen, Jiang-Fan, Jackson, Edwin K., Apasov, Sergey, Abrams, Scott, Sitkovsky, Michail
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 29.08.2006; National Acad Sciences
• Subjects: Adenosine; Adenosine - metabolism; Adenosine A2 Receptor Antagonists; Animals; Biological Sciences; Cancer; CD8-Positive T-Lymphocytes - immunology; Cell growth; Cell- and Tissue-Based Therapy; Humans; Hypoxia; Immunity (Disease); Immunotherapy, Adoptive; Inoculation; Interferon-gamma - biosynthesis; Lungs; Melanoma; Melanoma - immunology; Melanoma - metabolism; Melanoma - pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation - genetics; Purinergic P1 receptors; Receptor, Adenosine A2A - deficiency; Receptor, Adenosine A2A - metabolism; Rodents; T cell receptors; T lymphocytes; Tissues; Tumors

The A2A adenosine receptor (A2AR) has been shown to be a critical and nonredundant negative regulator of immune cells in protecting normal tissues from inflammatory damage. We hypothesized that A2AR also protects cancerous tissues by inhibiting incoming antitumor T lymphocytes. Here we confirm this...