The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells

• Published in: Cellular physiology and biochemistry Vol. 49; no. 4; pp. 1539 - 1550
• Main Authors: He, Jin-Hua, Li, Yu-Guang, Han, Ze-Ping, Zhou, Jia-Bin, Chen, Wei-Ming, Lv, Yu-Bing, He, Meng-Ling, Zuo, Ji-Dong, Zheng, Lei
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.10.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: 3' Untranslated Regions; Animals; Autophagy; Base Sequence; Bladder; Cancer therapies; Cell cycle; Cell growth; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotherapy; CircRNA-ACAP2; Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colorectal cancer; Feedback, Physiological; Gastric cancer; Gene expression; Hsa-miR-21-5p; Humans; Hypotheses; Invasion; Membrane Proteins - genetics; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; MicroRNAs - metabolism; Neoplasm Invasiveness; Original Paper; Patients; Proliferation; RNA - antagonists & inhibitors; RNA - genetics; RNA - metabolism; RNA Interference; RNA, Circular; RNA, Small Interfering - metabolism; RNA, Small Interfering - therapeutic use; Sequence Alignment; SW480 cells; T-Lymphoma Invasion and Metastasis-inducing Protein 1 - antagonists & inhibitors; T-Lymphoma Invasion and Metastasis-inducing Protein 1 - genetics; T-Lymphoma Invasion and Metastasis-inducing Protein 1 - metabolism; Tiam1; China; Tiam1; Colon cancer; SW480 cells; Proliferation; Hsa-miR-21-5p; CircRNA-ACAP2; Invasion

Background/Aims: Circular RNAs (circRNAs), a type of RNA that is widely expressed in human cells, have essential roles in the development and progression of cancer. CircRNAs contain microRNA (miRNA) binding sites and can function as miRNA sponges to regulate gene expression by removing the inhibitor...