AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

• Published in: Cellular physiology and biochemistry Vol. 46; no. 4; pp. 1381 - 1397
• Main Authors: Kosuru, Ramoji, Cai, Yin, Kandula, Vidya, Yan, Dan, Wang, Chunyan, Zheng, Hong, Li, Yalan, Irwin, Michael G., Singh, Sanjay, Xia, Zhengyuan
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.05.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: AMP-Activated Protein Kinases - antagonists & inhibitors; AMP-Activated Protein Kinases - metabolism; AMPK; Animals; Antidiabetics; Apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; Caspase 3; Cell Hypoxia; Cells, Cultured; Clinical trials; Coronary Vessels - injuries; Creatine Kinase, MB Form - blood; Diabetes; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - pathology; Drug dosages; Gene expression; Glucose; Glucose - pharmacology; Heart; Ischemia; Kinases; L-Lactate Dehydrogenase - blood; Laboratory animals; Male; Medical prognosis; Metabolism; Metabolites; Myocardial ischemia-reperfusion; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - prevention & control; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Original Paper; Oxidative stress; Oxidative Stress - drug effects; Phosphorylation - drug effects; Proto-Oncogene Proteins c-bcl-2 - metabolism; Pterostilbene; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Rodents; Stilbenes - pharmacology; Stilbenes - therapeutic use; Streptozocin - toxicity; Stress response; AMPK; Diabetes; Myocardial ischemia-reperfusion; Pterostilbene; Apoptosis

Background/Aims: Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes i...