AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis - Kosuru, Ramoji; Cai, Yin; Kandula, Vidya; Yan, Dan; Wang, Chunyan; Zheng, Hong; Li, Yalan; Irwin, Michael G.; Singh, Sanjay; Xia, Zhengyuan (Cellular physiology and biochemistry, 2018)
Keywords: AMP-Activated Protein Kinases - antagonists & inhibitors; AMP-Activated Protein Kinases - metabolism; AMPK; Animals; Antidiabetics; Apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; Caspase 3; Cell Hypoxia; Cells, Cultured; Clinical trials; Coronary Vessels - injuries; Creatine Kinase, MB Form - blood; Diabetes; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - pathology; Drug dosages; Gene expression; Glucose; Glucose - pharmacology; Heart; Ischemia; Kinases; L-Lactate Dehydrogenase - blood; Laboratory animals; Male; Medical prognosis; Metabolism; Metabolites; Myocardial ischemia-reperfusion; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - prevention & control; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Original Paper; Oxidative stress; Oxidative Stress - drug effects; Phosphorylation - drug effects; Proto-Oncogene Proteins c-bcl-2 - metabolism; Pterostilbene; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Rodents; Stilbenes - pharmacology; Stilbenes - therapeutic use; Streptozocin - toxicity; Stress response; AMPK; Diabetes; Myocardial ischemia-reperfusion; Pterostilbene; Apoptosis