Cell therapy for cardiac repair—lessons from clinical trials

• Published in: Nature reviews cardiology Vol. 11; no. 4; pp. 232 - 246
• Main Authors: Behfar, Atta, Crespo-Diaz, Ruben, Terzic, Andre, Gersh, Bernard J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2014; Nature Publishing Group
• Subjects: 692/699/75/2/1674; 692/699/75/230; 692/700/565/2319; Cardiac Imaging; Cardiac Surgery; Cardiology; Care and treatment; Cell- and Tissue-Based Therapy - methods; Cellular therapy; Clinical Trials as Topic; Heart diseases; Heart Diseases - therapy; Humans; Medicine & Public Health; Methods; Patient outcomes; review-article; Treatment Outcome

Key Points First-generation stem cells are comprised of unselected cell mixtures exemplified by unfractionated bone-marrow-derived mononuclear stem cells Initial stem-cell trials have established safety and feasibility, but show limited efficacy in the context of cardiovascular disease The main hurd...