Solidago virgaurea L. Plant Extract Targeted against Candida albicans to Reduce Oral Microbial Biomass: A Double Blind Randomized Trial on Healthy Adults
Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a...
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| Published in | Antibiotics (Basel) Vol. 9; no. 4; p. 137 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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25.03.2020
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| Abstract | Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups. |
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| AbstractList | Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro,
ssp.
L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus,
. It reduces the biomass of
-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group
= 33 vs. control
= 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)),
and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28
= 0.005 and ΔD14D28
= 0.026),
(ΔD0D14
= 0.024) and
(ΔD0D28
= 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28
= 0.062 and ΔD14D28
= 0.009). Plaque Index and Gingival Index improved in both groups. Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups.Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups. Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida- bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia[TM], Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load ([DELTA]D0D28 p = 0.005 and [DELTA]D14D28 p = 0.026), Streptococcus mutans ([DELTA]D0D14 p = 0.024) and C. albicans ([DELTA]D0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 ([DELTA]D0D28 p = 0.062 and [DELTA]D14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups. Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups. Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans . It reduces the biomass of Candida -bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups. |
| Audience | Academic |
| Author | Rolland, Yohan Hasseine, Lilia Orange, François Landreau, Anne Prêcheur, Isabelle Morisot, Adeline |
| AuthorAffiliation | 3 Givaudan, Naturex, 84140 Avignon, France; yohan.rolland@givaudan.com 8 Université d’Angers, Faculté de Santé, 49045 Angers, France 6 Université Nice Côte d’Azur, Centre Hospitalier Universitaire, Département de Santé Publique, 06200 Nice, France; morisot.a@chu-nice.fr 4 Université Nice Côte d’Azur, Centre Hospitalier Universitaire, Laboratoire de Parasitologie-Mycologie, 06200 Nice, France; hasseine.l@chu-nice.fr (L.H.); landreau.a@chu-nice.fr (A.L.) 5 Université Nice Côte d’Azur, Faculté des Sciences, Centre Commun de Microscopie Appliquée (CCMA), 06000 Nice, France; francois.orange@univ-cotedazur.fr 7 Université Nice Côte d’Azur, Institut de Chimie de Nice CNRS UMR 7272, MBVB, 06000 Nice, France 1 Université Nice Côte d’Azur, Faculté de Chirurgie Dentaire, Laboratoire Micoralis EA 7354, 06300 Nice, France 2 Université Nice Côte d’Azur, Centre Hospitalier Universitaire, Pôle Odontologie, 06200 Nice, France |
| AuthorAffiliation_xml | – name: 2 Université Nice Côte d’Azur, Centre Hospitalier Universitaire, Pôle Odontologie, 06200 Nice, France – name: 6 Université Nice Côte d’Azur, Centre Hospitalier Universitaire, Département de Santé Publique, 06200 Nice, France; morisot.a@chu-nice.fr – name: 7 Université Nice Côte d’Azur, Institut de Chimie de Nice CNRS UMR 7272, MBVB, 06000 Nice, France – name: 8 Université d’Angers, Faculté de Santé, 49045 Angers, France – name: 1 Université Nice Côte d’Azur, Faculté de Chirurgie Dentaire, Laboratoire Micoralis EA 7354, 06300 Nice, France – name: 3 Givaudan, Naturex, 84140 Avignon, France; yohan.rolland@givaudan.com – name: 4 Université Nice Côte d’Azur, Centre Hospitalier Universitaire, Laboratoire de Parasitologie-Mycologie, 06200 Nice, France; hasseine.l@chu-nice.fr (L.H.); landreau.a@chu-nice.fr (A.L.) – name: 5 Université Nice Côte d’Azur, Faculté des Sciences, Centre Commun de Microscopie Appliquée (CCMA), 06000 Nice, France; francois.orange@univ-cotedazur.fr |
| Author_xml | – sequence: 1 givenname: Isabelle orcidid: 0000-0001-8134-0127 surname: Prêcheur fullname: Prêcheur, Isabelle – sequence: 2 givenname: Yohan surname: Rolland fullname: Rolland, Yohan – sequence: 3 givenname: Lilia surname: Hasseine fullname: Hasseine, Lilia – sequence: 4 givenname: François surname: Orange fullname: Orange, François – sequence: 5 givenname: Adeline surname: Morisot fullname: Morisot, Adeline – sequence: 6 givenname: Anne surname: Landreau fullname: Landreau, Anne |
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| CitedBy_id | crossref_primary_10_33380_2305_2066_2022_11_3_91_96 crossref_primary_10_3166_phyto_2022_0342 crossref_primary_10_1007_s10787_024_01631_8 crossref_primary_10_1080_08927014_2021_1924693 |
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| Title | Solidago virgaurea L. Plant Extract Targeted against Candida albicans to Reduce Oral Microbial Biomass: A Double Blind Randomized Trial on Healthy Adults |
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