The landscape of human STR variation

Short tandem repeats are among the most polymorphic loci in the human genome. These loci play a role in the etiology of a range of genetic diseases and have been frequently utilized in forensics, population genetics, and genetic genealogy. Despite this plethora of applications, little is known about...

Full description

Saved in:
Bibliographic Details
Published inGenome research Vol. 24; no. 11; pp. 1894 - 1904
Main Authors Willems, Thomas, Gymrek, Melissa, Highnam, Gareth, Mittelman, David, Erlich, Yaniv
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.11.2014
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Short tandem repeats are among the most polymorphic loci in the human genome. These loci play a role in the etiology of a range of genetic diseases and have been frequently utilized in forensics, population genetics, and genetic genealogy. Despite this plethora of applications, little is known about the variation of most STRs in the human population. Here, we report the largest-scale analysis of human STR variation to date. We collected information for nearly 700,000 STR loci across more than 1000 individuals in Phase 1 of the 1000 Genomes Project. Extensive quality controls show that reliable allelic spectra can be obtained for close to 90% of the STR loci in the genome. We utilize this call set to analyze determinants of STR variation, assess the human reference genome's representation of STR alleles, find STR loci with common loss-of-function alleles, and obtain initial estimates of the linkage disequilibrium between STRs and common SNPs. Overall, these analyses further elucidate the scale of genetic variation beyond classical point mutations.
AbstractList Short tandem repeats are among the most polymorphic loci in the human genome. These loci play a role in the etiology of a range of genetic diseases and have been frequently utilized in forensics, population genetics, and genetic genealogy. Despite this plethora of applications, little is known about the variation of most STRs in the human population. Here, we report the largest-scale analysis of human STR variation to date. We collected information for nearly 700,000 STR loci across more than 1000 individuals in Phase 1 of the 1000 Genomes Project. Extensive quality controls show that reliable allelic spectra can be obtained for close to 90% of the STR loci in the genome. We utilize this call set to analyze determinants of STR variation, assess the human reference genome’s representation of STR alleles, find STR loci with common loss-of-function alleles, and obtain initial estimates of the linkage disequilibrium between STRs and common SNPs. Overall, these analyses further elucidate the scale of genetic variation beyond classical point mutations.
Author Erlich, Yaniv
Mittelman, David
Gymrek, Melissa
Highnam, Gareth
Willems, Thomas
Author_xml – sequence: 1
  givenname: Thomas
  surname: Willems
  fullname: Willems, Thomas
  organization: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Computational and Systems Biology Program, MIT, Cambridge, Massachusetts 02139, USA
– sequence: 2
  givenname: Melissa
  surname: Gymrek
  fullname: Gymrek, Melissa
  organization: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts 02139, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA; Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
– sequence: 3
  givenname: Gareth
  surname: Highnam
  fullname: Highnam, Gareth
  organization: Virginia Bioinformatics Institute and Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA
– sequence: 4
  givenname: David
  surname: Mittelman
  fullname: Mittelman, David
  organization: Virginia Bioinformatics Institute and Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA; Gene by Gene, Ltd., Houston, Texas 77008, USA
– sequence: 5
  givenname: Yaniv
  surname: Erlich
  fullname: Erlich, Yaniv
  email: yaniv@wi.mit.edu
  organization: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; yaniv@wi.mit.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25135957$$D View this record in MEDLINE/PubMed
BookMark eNqNkctLAzEQxoNU7EOPXmUPHrxsnWweu7kIUnxBQdB6DmmSbVd2NzXZLfjfm9IqenMuM8P8-PhmZowGrWstQucYphgDvl75Kc5j0NjSIzTCjIqUUS4GsYaiSAUwPETjEN4BgNCiOEHDjGHCBMtH6HKxtkmtWhO02tjElcm6b1SbvC5ekq3yleoq156i41LVwZ4d8gS93d8tZo_p_PnhaXY7TzUj0KWGLSm3BqKyxthkXCkGIITOhTF4SYS2ucqihRJsCUpjY3OqsOKKcEKgJBN0s9fd9MvGGm3bzqtabnzVKP8pnark30lbreXKbSXNMBeZiAJXBwHvPnobOtlUQds6LmhdHyTmOSG5KDj7B5oBK3gBOzTdo9q7ELwtfxxhkLsnyJWX-yfElkb-4vcaP_T31ckXpRqDBg
CitedBy_id crossref_primary_10_1080_15476286_2018_1536593
crossref_primary_10_1186_s12711_021_00631_4
crossref_primary_10_1101_gr_185892_114
crossref_primary_10_1186_s13100_023_00302_9
crossref_primary_10_1002_gcc_22904
crossref_primary_10_3389_fgene_2023_1145285
crossref_primary_10_1016_j_jad_2018_02_046
crossref_primary_10_1155_2023_6152905
crossref_primary_10_1089_bio_2021_0042
crossref_primary_10_1016_j_tig_2019_01_002
crossref_primary_10_1038_s41598_020_77081_3
crossref_primary_10_3389_fbinf_2021_695784
crossref_primary_10_3389_fgene_2017_00133
crossref_primary_10_1038_s41380_022_01857_4
crossref_primary_10_1038_s41598_024_53739_0
crossref_primary_10_3390_genes13122205
crossref_primary_10_1073_pnas_1619944114
crossref_primary_10_3389_fbinf_2021_691865
crossref_primary_10_1002_elps_202100143
crossref_primary_10_1101_gr_214007_116
crossref_primary_10_3389_fgene_2022_810595
crossref_primary_10_1016_j_jmb_2023_168260
crossref_primary_10_1093_nar_gkab224
crossref_primary_10_1016_j_crmeth_2021_100054
crossref_primary_10_1093_bioinformatics_bty791
crossref_primary_10_1093_nar_gky538
crossref_primary_10_1186_s12920_018_0446_7
crossref_primary_10_1080_10495398_2021_2009845
crossref_primary_10_1093_nar_gkz501
crossref_primary_10_1038_nmeth_4267
crossref_primary_10_1038_s41598_017_16700_y
crossref_primary_10_1016_j_rprh_2015_12_007
crossref_primary_10_1093_gbe_evae017
crossref_primary_10_1080_03014460_2021_2010804
crossref_primary_10_3389_fdata_2021_727216
crossref_primary_10_1371_journal_pgen_1009604
crossref_primary_10_1016_j_ajhg_2021_03_011
crossref_primary_10_1101_gr_277057_122
crossref_primary_10_1371_journal_pone_0180356
crossref_primary_10_1093_emph_eoz005
crossref_primary_10_3390_genes13010044
crossref_primary_10_1101_sqb_2015_80_027623
crossref_primary_10_3389_fgene_2022_815089
crossref_primary_10_1038_s41467_023_42278_3
crossref_primary_10_1016_j_iatssr_2019_05_001
crossref_primary_10_1038_s41576_024_00696_z
crossref_primary_10_1101_gr_190868_115
crossref_primary_10_1093_bioinformatics_btw568
crossref_primary_10_1016_j_ccell_2014_10_004
crossref_primary_10_1186_s13073_014_0089_z
crossref_primary_10_1016_j_heliyon_2018_e00625
crossref_primary_10_1038_s41467_021_23143_7
crossref_primary_10_1038_s41467_021_22206_z
crossref_primary_10_1111_1744_7917_12577
crossref_primary_10_1038_s41586_020_2579_z
crossref_primary_10_3390_ijms20184450
crossref_primary_10_1016_j_jalz_2015_05_011
crossref_primary_10_1128_spectrum_02645_22
crossref_primary_10_1002_wfs2_1390
crossref_primary_10_1038_s41431_024_01666_z
crossref_primary_10_1038_s41398_023_02689_8
crossref_primary_10_3389_fcimb_2019_00082
crossref_primary_10_1038_nrg_2017_115
crossref_primary_10_1016_j_fsir_2022_100298
crossref_primary_10_1016_j_isci_2023_107992
crossref_primary_10_1016_j_fsigen_2022_102676
crossref_primary_10_1093_nar_gkw219
crossref_primary_10_1016_j_fsigen_2018_08_011
crossref_primary_10_1093_nar_gky1318
crossref_primary_10_1016_j_neubiorev_2021_06_028
crossref_primary_10_1111_jeb_14106
crossref_primary_10_1007_s12031_021_01850_6
crossref_primary_10_12688_f1000research_22639_1
crossref_primary_10_1038_ng_3952
crossref_primary_10_1515_medgen_2021_2099
crossref_primary_10_1038_s41467_017_01586_1
crossref_primary_10_1186_s13100_020_00206_y
crossref_primary_10_1038_s41598_017_02600_8
crossref_primary_10_3389_fgene_2018_00155
crossref_primary_10_1016_j_fsigss_2019_09_084
crossref_primary_10_1101_gr_231449_117
crossref_primary_10_1007_s11033_018_4264_y
crossref_primary_10_1080_03014460_2017_1414877
crossref_primary_10_1515_medgen_2021_2097
crossref_primary_10_4103_jfsm_jfsm_36_23
crossref_primary_10_1038_s41380_021_01329_1
crossref_primary_10_1093_dnares_dsw013
crossref_primary_10_1186_s13059_019_1909_7
crossref_primary_10_1186_s12864_018_4616_y
crossref_primary_10_1080_23808993_2017_1286227
crossref_primary_10_1042_BST20200143
crossref_primary_10_1016_j_semcdb_2020_10_003
crossref_primary_10_1038_s41467_023_37690_8
crossref_primary_10_3389_fpsyt_2023_1236540
crossref_primary_10_7717_peerj_9085
crossref_primary_10_1016_j_mce_2019_05_001
crossref_primary_10_1371_journal_pcbi_1007968
crossref_primary_10_1007_s11910_016_0643_8
crossref_primary_10_1007_s10048_018_0546_8
crossref_primary_10_3389_fgene_2018_00428
crossref_primary_10_1534_genetics_115_180539
crossref_primary_10_1373_clinchem_2014_235499
crossref_primary_10_1007_s15016_022_2942_4
crossref_primary_10_3390_jcm10173934
crossref_primary_10_1371_journal_pone_0225216
crossref_primary_10_1038_ncomms14291
crossref_primary_10_3389_fgene_2019_00992
crossref_primary_10_1038_ng_3461
crossref_primary_10_1016_j_fsigen_2022_102776
crossref_primary_10_1038_s41467_018_06694_0
crossref_primary_10_1002_humu_23023
crossref_primary_10_1371_journal_pone_0300545
crossref_primary_10_1101_gr_278070_123
crossref_primary_10_1093_bioinformatics_btaa440
crossref_primary_10_1093_bioinformatics_btz041
crossref_primary_10_1128_JCM_02032_21
crossref_primary_10_26508_lsa_201900364
crossref_primary_10_1186_s12936_023_04541_2
crossref_primary_10_1038_s41576_024_00692_3
crossref_primary_10_1016_j_jid_2016_01_037
crossref_primary_10_1101_gr_184879_114
crossref_primary_10_1007_s12031_018_1208_x
crossref_primary_10_7554_eLife_84043
crossref_primary_10_1080_03014460_2020_1736628
crossref_primary_10_1016_j_cell_2019_02_032
crossref_primary_10_1038_s41588_019_0521_9
crossref_primary_10_3389_fbinf_2021_685844
crossref_primary_10_1016_j_gde_2017_01_014
crossref_primary_10_1016_j_ajhg_2016_04_001
crossref_primary_10_3389_fonc_2023_1225538
crossref_primary_10_1038_s41598_018_32945_7
crossref_primary_10_1016_j_fsigen_2023_102946
crossref_primary_10_1002_alz_13168
crossref_primary_10_1038_s41587_024_02225_z
crossref_primary_10_3390_molecules23040850
crossref_primary_10_1093_genetics_iyad161
crossref_primary_10_1093_nar_gkx574
crossref_primary_10_1128_spectrum_04618_22
crossref_primary_10_1016_j_fsigen_2015_01_001
crossref_primary_10_3389_fgene_2018_00520
crossref_primary_10_3390_insects12090832
crossref_primary_10_1016_j_legalmed_2017_11_004
crossref_primary_10_1073_pnas_2121024119
crossref_primary_10_1002_ajhb_23139
crossref_primary_10_1186_s12864_016_3448_x
crossref_primary_10_1038_s41598_022_17267_z
crossref_primary_10_1371_journal_pone_0219279
crossref_primary_10_15252_embj_201899793
crossref_primary_10_1534_g3_119_400771
crossref_primary_10_1134_S0026893322030049
crossref_primary_10_1101_gr_231753_117
crossref_primary_10_1093_nar_gkx867
crossref_primary_10_1038_s41598_020_76016_2
crossref_primary_10_1038_srep38225
crossref_primary_10_1093_gbe_evx164
crossref_primary_10_1038_srep31791
crossref_primary_10_1002_ajpa_24341
crossref_primary_10_1186_s12859_017_1800_z
crossref_primary_10_1186_s12881_017_0374_y
crossref_primary_10_1016_j_gde_2017_01_012
crossref_primary_10_1080_14737159_2019_1568874
crossref_primary_10_7124_bc_000A10
crossref_primary_10_3389_fgene_2018_00630
crossref_primary_10_1007_s00439_022_02484_3
Cites_doi 10.1126/science.1078311
10.1016/S0014-5793(99)00863-7
10.1093/hmg/ddh251
10.1038/74249
10.1093/nar/27.2.573
10.1038/nsb875
10.1038/ng836
10.1038/nrg1962-c2
10.1111/j.1538-7836.2009.03520.x
10.1093/gbe/evq046
10.1038/ng.2543
10.1038/nrg2952
10.1016/j.ajhg.2008.02.018
10.1182/blood-2009-03-213504
10.1093/bioinformatics/btp352
10.1186/1471-2164-10-612
10.1038/nrg1689
10.1086/302011
10.1371/journal.pone.0033036
10.1371/journal.pgen.0010070
10.1126/science.1170097
10.1073/pnas.1221891110
10.1038/ng0298-164
10.1016/j.ajhg.2010.08.006
10.1093/genetics/164.2.781
10.1016/j.gene.2012.12.068
10.1520/JFS14601J
10.1038/nrg3029
10.1038/nrg1707
10.1101/006387
10.1126/science.278.5346.2117
10.1101/gr.135780.111
10.1093/molbev/msg228
10.1038/ng.2398
10.1038/nature05977
10.1093/molbev/msq198
10.1093/nar/29.1.320
10.1093/genetics/164.4.1567
10.1101/gr.7113408
10.1093/hmg/ddi234
10.1186/1471-2105-8-125
10.1038/nrg1348
10.1073/pnas.0907112106
10.1101/gr.122937.111
10.1146/annurev-genet-072610-155046
10.1186/gb4141
10.1093/hmg/2.8.1123
10.1038/74238
10.1101/gr.115956.110
10.1038/nature08494
10.1093/hmg/2.4.411
10.1073/pnas.0400182101
10.1093/nar/gku212
10.1074/jbc.274.19.13176
10.1126/science.1229566
10.1093/nar/gks726
10.1038/nrg3117
10.1093/genetics/139.1.457
10.1111/j.1471-8286.2005.01155.x
10.1101/gr.148718.112
10.1093/gbe/evs116
10.1002/bies.20470
10.1590/S1415-47572006000200018
10.1038/nature11632
10.1093/nar/gks981
10.1073/pnas.94.3.1041
10.1101/gr.114777.110
10.1126/science.1219240
10.1093/oxfordjournals.molbev.a026411
10.1126/science.1061573
ContentType Journal Article
Copyright 2014 Willems et al.; Published by Cold Spring Harbor Laboratory Press.
2014
Copyright_xml – notice: 2014 Willems et al.; Published by Cold Spring Harbor Laboratory Press.
– notice: 2014
CorporateAuthor 1000 Genomes Project Consortium
The 1000 Genomes Project Consortium
CorporateAuthor_xml – sequence: 0
  name: The 1000 Genomes Project Consortium
– name: 1000 Genomes Project Consortium
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
7TM
8FD
FR3
P64
RC3
5PM
DOI 10.1101/gr.177774.114
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Nucleic Acids Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
Genetics Abstracts
Engineering Research Database
Technology Research Database
Nucleic Acids Abstracts
Biotechnology and BioEngineering Abstracts
DatabaseTitleList CrossRef
MEDLINE - Academic
Genetics Abstracts

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
Biology
DocumentTitleAlternate Willems et al
EISSN 1549-5469
EndPage 1904
ExternalDocumentID 10_1101_gr_177774_114
25135957
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
.GJ
18M
29H
2WC
39C
4.4
53G
5GY
5RE
5VS
AAYOK
AAZTW
ABDIX
ABDNZ
ACGFO
ACYGS
ADBBV
ADNWM
AEILP
AENEX
AI.
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
C1A
CGR
CS3
CUY
CVF
DIK
DU5
E3Z
EBS
ECM
EIF
EJD
F5P
FRP
GX1
H13
HYE
IH2
K-O
KQ8
MV1
NPM
R.V
RCX
RHF
RHI
RNS
RPM
RXW
SJN
TAE
TR2
VH1
W8F
WOQ
YKV
ZCG
ZGI
ZXP
AAYXX
CITATION
7X8
7TM
8FD
FR3
P64
RC3
5PM
ABRJW
ID FETCH-LOGICAL-c530t-d5b46ed0595c11d26aa50099c79dd1b39ce7a2348f0ef0ac1de74a1a6a36330f3
IEDL.DBID RPM
ISSN 1088-9051
IngestDate Tue Sep 17 21:26:44 EDT 2024
Fri Oct 25 06:23:20 EDT 2024
Sat Oct 26 06:06:36 EDT 2024
Fri Dec 06 00:36:29 EST 2024
Sat Nov 02 12:24:32 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
License 2014 Willems et al.; Published by Cold Spring Harbor Laboratory Press.
This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c530t-d5b46ed0595c11d26aa50099c79dd1b39ce7a2348f0ef0ac1de74a1a6a36330f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216929/
PMID 25135957
PQID 1620586805
PQPubID 23479
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4216929
proquest_miscellaneous_1673379865
proquest_miscellaneous_1620586805
crossref_primary_10_1101_gr_177774_114
pubmed_primary_25135957
PublicationCentury 2000
PublicationDate 2014-11-01
PublicationDateYYYYMMDD 2014-11-01
PublicationDate_xml – month: 11
  year: 2014
  text: 2014-11-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Genome research
PublicationTitleAlternate Genome Res
PublicationYear 2014
Publisher Cold Spring Harbor Laboratory Press
Publisher_xml – name: Cold Spring Harbor Laboratory Press
References 2021111811123789000_24.11.1894.29
Budowle (2021111811123789000_24.11.1894.9) 1999; 44
2021111811123789000_24.11.1894.21
2021111811123789000_24.11.1894.65
2021111811123789000_24.11.1894.22
2021111811123789000_24.11.1894.66
2021111811123789000_24.11.1894.23
2021111811123789000_24.11.1894.67
2021111811123789000_24.11.1894.24
2021111811123789000_24.11.1894.68
2021111811123789000_24.11.1894.25
2021111811123789000_24.11.1894.26
2021111811123789000_24.11.1894.27
2021111811123789000_24.11.1894.28
2021111811123789000_24.11.1894.61
2021111811123789000_24.11.1894.62
2021111811123789000_24.11.1894.63
2021111811123789000_24.11.1894.20
2021111811123789000_24.11.1894.64
2021111811123789000_24.11.1894.32
2021111811123789000_24.11.1894.33
Falush (2021111811123789000_24.11.1894.18) 2003; 164
2021111811123789000_24.11.1894.34
2021111811123789000_24.11.1894.35
2021111811123789000_24.11.1894.36
2021111811123789000_24.11.1894.37
2021111811123789000_24.11.1894.38
2021111811123789000_24.11.1894.39
Slatkin (2021111811123789000_24.11.1894.60) 1995; 139
2021111811123789000_24.11.1894.70
2021111811123789000_24.11.1894.30
2021111811123789000_24.11.1894.31
2021111811123789000_24.11.1894.2
2021111811123789000_24.11.1894.43
2021111811123789000_24.11.1894.1
2021111811123789000_24.11.1894.44
2021111811123789000_24.11.1894.4
2021111811123789000_24.11.1894.45
2021111811123789000_24.11.1894.3
2021111811123789000_24.11.1894.46
2021111811123789000_24.11.1894.6
2021111811123789000_24.11.1894.47
2021111811123789000_24.11.1894.5
2021111811123789000_24.11.1894.48
2021111811123789000_24.11.1894.8
2021111811123789000_24.11.1894.49
2021111811123789000_24.11.1894.7
2021111811123789000_24.11.1894.40
2021111811123789000_24.11.1894.41
2021111811123789000_24.11.1894.42
2021111811123789000_24.11.1894.19
2021111811123789000_24.11.1894.10
2021111811123789000_24.11.1894.54
2021111811123789000_24.11.1894.11
2021111811123789000_24.11.1894.55
2021111811123789000_24.11.1894.12
2021111811123789000_24.11.1894.56
2021111811123789000_24.11.1894.13
2021111811123789000_24.11.1894.57
Whittaker (2021111811123789000_24.11.1894.69) 2003; 164
2021111811123789000_24.11.1894.14
2021111811123789000_24.11.1894.58
2021111811123789000_24.11.1894.15
2021111811123789000_24.11.1894.59
2021111811123789000_24.11.1894.16
2021111811123789000_24.11.1894.17
2021111811123789000_24.11.1894.50
2021111811123789000_24.11.1894.51
2021111811123789000_24.11.1894.52
2021111811123789000_24.11.1894.53
References_xml – ident: 2021111811123789000_24.11.1894.53
  doi: 10.1126/science.1078311
– ident: 2021111811123789000_24.11.1894.59
  doi: 10.1016/S0014-5793(99)00863-7
– ident: 2021111811123789000_24.11.1894.2
  doi: 10.1093/hmg/ddh251
– ident: 2021111811123789000_24.11.1894.15
  doi: 10.1038/74249
– ident: 2021111811123789000_24.11.1894.6
  doi: 10.1093/nar/27.2.573
– ident: 2021111811123789000_24.11.1894.29
  doi: 10.1038/nsb875
– ident: 2021111811123789000_24.11.1894.12
  doi: 10.1038/ng836
– ident: 2021111811123789000_24.11.1894.30
  doi: 10.1038/nrg1962-c2
– ident: 2021111811123789000_24.11.1894.26
  doi: 10.1111/j.1538-7836.2009.03520.x
– ident: 2021111811123789000_24.11.1894.33
  doi: 10.1093/gbe/evq046
– ident: 2021111811123789000_24.11.1894.36
  doi: 10.1038/ng.2543
– ident: 2021111811123789000_24.11.1894.31
  doi: 10.1038/nrg2952
– ident: 2021111811123789000_24.11.1894.46
  doi: 10.1016/j.ajhg.2008.02.018
– ident: 2021111811123789000_24.11.1894.14
  doi: 10.1182/blood-2009-03-213504
– ident: 2021111811123789000_24.11.1894.39
  doi: 10.1093/bioinformatics/btp352
– ident: 2021111811123789000_24.11.1894.49
  doi: 10.1186/1471-2164-10-612
– ident: 2021111811123789000_24.11.1894.48
  doi: 10.1038/nrg1689
– ident: 2021111811123789000_24.11.1894.8
  doi: 10.1086/302011
– ident: 2021111811123789000_24.11.1894.19
  doi: 10.1371/journal.pone.0033036
– ident: 2021111811123789000_24.11.1894.54
  doi: 10.1371/journal.pgen.0010070
– ident: 2021111811123789000_24.11.1894.67
  doi: 10.1126/science.1170097
– ident: 2021111811123789000_24.11.1894.56
  doi: 10.1073/pnas.1221891110
– ident: 2021111811123789000_24.11.1894.7
  doi: 10.1038/ng0298-164
– ident: 2021111811123789000_24.11.1894.5
  doi: 10.1016/j.ajhg.2010.08.006
– volume: 164
  start-page: 781
  year: 2003
  ident: 2021111811123789000_24.11.1894.69
  article-title: Likelihood-based estimation of microsatellite mutation rates
  publication-title: Genetics
  doi: 10.1093/genetics/164.2.781
  contributor:
    fullname: Whittaker
– ident: 2021111811123789000_24.11.1894.41
  doi: 10.1016/j.gene.2012.12.068
– volume: 44
  start-page: 1277
  year: 1999
  ident: 2021111811123789000_24.11.1894.9
  article-title: Population data on the thirteen CODIS core short tandem repeat loci in African Americans, U.S. Caucasians, Hispanics, Bahamians, Jamaicans, and Trinidadians
  publication-title: J Forensic Sci
  doi: 10.1520/JFS14601J
  contributor:
    fullname: Budowle
– ident: 2021111811123789000_24.11.1894.61
  doi: 10.1038/nrg3029
– ident: 2021111811123789000_24.11.1894.50
  doi: 10.1038/nrg1707
– ident: 2021111811123789000_24.11.1894.51
  doi: 10.1101/006387
– ident: 2021111811123789000_24.11.1894.57
  doi: 10.1126/science.278.5346.2117
– ident: 2021111811123789000_24.11.1894.22
  doi: 10.1101/gr.135780.111
– ident: 2021111811123789000_24.11.1894.37
  doi: 10.1093/molbev/msg228
– ident: 2021111811123789000_24.11.1894.62
  doi: 10.1038/ng.2398
– ident: 2021111811123789000_24.11.1894.42
  doi: 10.1038/nature05977
– ident: 2021111811123789000_24.11.1894.47
  doi: 10.1093/molbev/msq198
– ident: 2021111811123789000_24.11.1894.55
  doi: 10.1093/nar/29.1.320
– volume: 164
  start-page: 1567
  year: 2003
  ident: 2021111811123789000_24.11.1894.18
  article-title: Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
  publication-title: Genetics
  doi: 10.1093/genetics/164.4.1567
  contributor:
    fullname: Falush
– ident: 2021111811123789000_24.11.1894.32
  doi: 10.1101/gr.7113408
– ident: 2021111811123789000_24.11.1894.63
  doi: 10.1093/hmg/ddi234
– ident: 2021111811123789000_24.11.1894.38
  doi: 10.1186/1471-2105-8-125
– ident: 2021111811123789000_24.11.1894.16
  doi: 10.1038/nrg1348
– ident: 2021111811123789000_24.11.1894.43
  doi: 10.1073/pnas.0907112106
– ident: 2021111811123789000_24.11.1894.34
  doi: 10.1101/gr.122937.111
– ident: 2021111811123789000_24.11.1894.21
  doi: 10.1146/annurev-genet-072610-155046
– ident: 2021111811123789000_24.11.1894.35
  doi: 10.1186/gb4141
– ident: 2021111811123789000_24.11.1894.68
  doi: 10.1093/hmg/2.8.1123
– ident: 2021111811123789000_24.11.1894.70
  doi: 10.1038/74238
– ident: 2021111811123789000_24.11.1894.28
  doi: 10.1101/gr.115956.110
– ident: 2021111811123789000_24.11.1894.40
  doi: 10.1038/nature08494
– ident: 2021111811123789000_24.11.1894.24
  doi: 10.1093/hmg/2.4.411
– ident: 2021111811123789000_24.11.1894.25
  doi: 10.1073/pnas.0400182101
– ident: 2021111811123789000_24.11.1894.13
  doi: 10.1093/nar/gku212
– ident: 2021111811123789000_24.11.1894.20
  doi: 10.1074/jbc.274.19.13176
– ident: 2021111811123789000_24.11.1894.23
  doi: 10.1126/science.1229566
– ident: 2021111811123789000_24.11.1894.58
  doi: 10.1093/nar/gks726
– ident: 2021111811123789000_24.11.1894.66
  doi: 10.1038/nrg3117
– volume: 139
  start-page: 457
  year: 1995
  ident: 2021111811123789000_24.11.1894.60
  article-title: A measure of population subdivision based on microsatellite allele frequencies
  publication-title: Genetics
  doi: 10.1093/genetics/139.1.457
  contributor:
    fullname: Slatkin
– ident: 2021111811123789000_24.11.1894.52
  doi: 10.1111/j.1471-8286.2005.01155.x
– ident: 2021111811123789000_24.11.1894.44
  doi: 10.1101/gr.148718.112
– ident: 2021111811123789000_24.11.1894.3
  doi: 10.1093/gbe/evs116
– ident: 2021111811123789000_24.11.1894.10
  doi: 10.1002/bies.20470
– ident: 2021111811123789000_24.11.1894.45
  doi: 10.1590/S1415-47572006000200018
– ident: 2021111811123789000_24.11.1894.1
  doi: 10.1038/nature11632
– ident: 2021111811123789000_24.11.1894.27
  doi: 10.1093/nar/gks981
– ident: 2021111811123789000_24.11.1894.11
  doi: 10.1073/pnas.94.3.1041
– ident: 2021111811123789000_24.11.1894.17
  doi: 10.1101/gr.114777.110
– ident: 2021111811123789000_24.11.1894.64
  doi: 10.1126/science.1219240
– ident: 2021111811123789000_24.11.1894.4
  doi: 10.1093/oxfordjournals.molbev.a026411
– ident: 2021111811123789000_24.11.1894.65
  doi: 10.1126/science.1061573
SSID ssj0003488
Score 2.583596
Snippet Short tandem repeats are among the most polymorphic loci in the human genome. These loci play a role in the etiology of a range of genetic diseases and have...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 1894
SubjectTerms Alleles
Gene Frequency
Genetic Variation
Genetics, Population - methods
Genome, Human - genetics
Genomics - methods
Genotype
Humans
Linkage Disequilibrium
Microsatellite Repeats - genetics
Polymorphism, Single Nucleotide
Resource
Title The landscape of human STR variation
URI https://www.ncbi.nlm.nih.gov/pubmed/25135957
https://search.proquest.com/docview/1620586805
https://search.proquest.com/docview/1673379865
https://pubmed.ncbi.nlm.nih.gov/PMC4216929
Volume 24
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEB60IHoR39YXK4i3tLvZR5pjLYoPFPEB3sJms6uCTaVWwX_v7KYpVsGDOQV2QpKZYeebZOYbgAPtuMQ1G1EZ20hYk0baKRlRp3TObSFdGDZxeaVO78X5g3yYAVn3woSifZM_t8qXfqt8fgq1la99067rxNrXlz0RM4VhvT0Lsxh-6xR9vP1y0an639AFPPnUhFiTtR-HLZbgITxDrqcBlsz3pSbTMekX0PxZL_ktAJ0sweIYOZJu9YTLMGPLFVjtlpg19z_JIQm1nOEj-QrMHdVn8716otsqHKBPkNDb66ueyMCRMKGP3N7dkA_MmYOR1uD-5PiudxqNpyRERnI6igqZC2ULhEnSMFbESvshB2lqkrQoWM5TYxMdo1YctY5qwwqbCM200lxxTh1fh0Y5KO0mkBjzGeu4UZw5Uag4ldThjpBjEJdSW9aEw1pP2WtFhpGFJIKy7HGYVbr1fc5N2K-1mOE7-n8QurSD97eMqZjKjupQ-ZdMwnmSdhTKbFSan9yuNlkTkimbTAQ8Xfb0CnpRoM0ee83Wv6_chgWES6LqRNyBxmj4bncRkozyPQTjZxd7wRG_AHoA390
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS-NAEB_8QPTl8OPUnh-3gviWdjf7keZRi1I9K-JV8C1sNrsq2FR69cD_3tlNU6yCD-YpsBOSzAw7M8lvfgNwqB2XuGYjKmMbCWvSSDslI-qUzrktpAvDJnpXqnsrLu7k3RzIuhcmgPZN_tgsnwbN8vEhYCufB6ZV48Ra172OiJnCsN6ah0XJk5TVRfpkA-aiXXXAoRN4-qkptSZr3Y-aLMFDeI5cTwQsme9MTWaj0qdU8yNi8l0IOluFH5PckRxXz7gGc7Zch43jEuvmwSs5IgHNGT6Tr8PSSX223Klnum3AIXoFCd29HvdEho6EGX3kb_-G_MeqOZjpJ9yenfY73WgyJyEyktNxVMhcKFtgoiQNY0WstB9zkKYmSYuC5Tw1NtExasVR66g2rLCJ0EwrzRXn1PFNWCiHpd0GEmNFYx03ijMnChWnkjrcE3IM41JqyxpwVOspe67oMLJQRlCW3Y-ySre-07kBB7UWM3xH_xdCl3b48i9jKqayrdpUfiWTcDRsW6HMVqX56e1qkzUgmbHJVMATZs-uoB8F4uyJ3_z69pW_Ybnb711ml-dXf3ZgBZMnUfUl7sLCePRi9zBBGef7wR3fACd24jk
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Za9tAEB6alKZ9KW2Oxj23EPIma1d7yHpM3ZrchByQN7HawwnEsnGdQv99Z1eWiRPIQ_Uk2BGSZoadGembbwB2tOcS11xCZeYS4UyRaK9kQr3SFXdW-jhs4uRU7V-Jw2t5_WDUVwTtm-q2W9-NuvXtTcRWTkYmbXFi6dlJX2RMYVhPJ9anK_BScnSytlCfb8Jc9JouOHSEQEG1oNdk6XDaZTkeIvDkBjJgyUJ3ar4cmZ6km49Rkw_C0OAdvJ3nj2Svec738MLV67CxV2PtPPpLdklEdMZP5evw6kd79rrfznXbgB30DBI7fAP2iYw9iXP6yMXlOfmDlXM01SZcDX5d9veT-ayExEhOZ4mVlVDOYrIkDWM2UzqMOigKkxfWsooXxuU6Q6146jzVhlmXC8200lxxTj3fgtV6XLttIBlWNc5zozjzwqqskNTjvlBhKJdSO9aB3VZP5aShxChjKUFZOZyWjW5Dt3MHvrdaLPEdw58IXbvx_e-SqYzKnupR-ZxMztGwPYUyHxrNL27XmqwD-ZJNFgKBNHt5BX0pkmfPfefjf1_5DdbOfg7K44PTo0_wBvMn0bQmfobV2fTefcEcZVZ9jd74D4Cl40w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+landscape+of+human+STR+variation&rft.jtitle=Genome+research&rft.au=Willems%2C+Thomas&rft.au=Gymrek%2C+Melissa&rft.au=Highnam%2C+Gareth&rft.au=Mittelman%2C+David&rft.date=2014-11-01&rft.pub=Cold+Spring+Harbor+Laboratory+Press&rft.issn=1088-9051&rft.eissn=1549-5469&rft.volume=24&rft.issue=11&rft.spage=1894&rft.epage=1904&rft_id=info:doi/10.1101%2Fgr.177774.114&rft_id=info%3Apmid%2F25135957&rft.externalDBID=PMC4216929
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1088-9051&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1088-9051&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1088-9051&client=summon