Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

• Published in: Genes & diseases Vol. 11; no. 3; p. 101087
• Main Authors: Mao, Yukun, Hou, Xueying, Fu, Su, Luan, Jie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024; Chongqing Medical University; KeAi Communications Co., Ltd
• Subjects: Biomarker; Breast capsular contracture; Full Length; Immune infiltration; Machine learning algorithms; PRKAR2B; Biomarker; Machine learning algorithms; Breast capsular contracture; PRKAR2B; Immune infiltration

Capsular contracture is a prevalent and severe complication that affects the postoperative outcomes of patients who receive silicone breast implants. At present, prosthesis replacement is the major treatment for capsular contracture after both breast augmentation procedures and breast reconstruction...