Genetic Determinants of Virulence between Two Foot-and-Mouth Disease Virus Isolates Which Caused Outbreaks of Differing Severity

• Published in: mSphere Vol. 4; no. 4
• Main Authors: Nishi, Tatsuya, Morioka, Kazuki, Saito, Nobuko, Yamakawa, Makoto, Kanno, Toru, Fukai, Katsuhiko
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 14.08.2019
• Subjects: Amino acids; Animals; Animals, Suckling; Antiviral agents; Bovidae; Capsid Proteins - chemistry; Capsid Proteins - genetics; Cattle; Cell culture; Cell Line; Cell lines; Cloning; Disease Outbreaks; DNA-directed RNA polymerase; Fever; Fidelity; Foot & mouth disease; Foot-and-Mouth Disease - mortality; Foot-and-Mouth Disease - virology; foot-and-mouth disease virus; Foot-and-Mouth Disease Virus - genetics; Foot-and-Mouth Disease Virus - pathogenicity; Genes; genetic determinants; Genomes; Infections; Infectivity; Mice; Molecular Biology and Physiology; Molecular modelling; Mortality; Mutation; Outbreaks; Pathogenicity; Recombinants; Replication; RNA, Viral - genetics; RNA-directed RNA polymerase; Serotypes; Signs; Strains (organisms); Studies; Suckling behavior; Tissue culture; Virulence; Virulence Factors - genetics; Viruses; VP1 protein; Japan; virulence; foot-and-mouth disease virus; genetic determinants

Efforts to understand the universal mechanism of foot-and-mouth disease virus (FMDV) infection may be aided by knowledge of the molecular mechanisms which underlie differences in virulence beyond multiple topotypes and serotypes of FMDV. Here, we demonstrated independent genetic determinants of two...