Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment

• Published in: Nature reviews. Nephrology Vol. 13; no. 11; pp. 697 - 711
• Main Authors: Wang, Ying, Bellomo, Rinaldo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2017; Nature Publishing Group
• Subjects: 692/4019/592/75; 692/4022/1585/4; 692/499; 692/53/2422; 692/700/565/545; Acute Kidney Injury - etiology; Acute Kidney Injury - physiopathology; Acute Kidney Injury - therapy; Biological markers; Cardiac Surgical Procedures - adverse effects; Complications and side effects; Glomerular Filtration Rate; Heart surgery; Humans; Identification and classification; Kidney diseases; Kidneys; Medical prognosis; Medicine & Public Health; Nephrology; Postoperative Complications; Prognosis; Renal Replacement Therapy - methods; review-article; Risk factors

Key Points CSA-AKI is the second most common cause of AKI in the intensive care setting and is associated with increased mortality The pathophysiology of CSA-AKI is very complex and probably includes renal ischaemia–reperfusion injury, inflammation, oxidative stress, haemolysis and nephrotoxins To d...