How to Become a Uropathogen: Comparative Genomic Analysis of Extraintestinal Pathogenic Escherichia coli Strains

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 34; pp. 12879 - 12884
• Main Authors: Brzuszkiewicz, Elzbieta, Brüggemann, Holger, Liesegang, Heiko, Emmerth, Melanie, Ölschläger, Tobias, Nagy, Gábor, Albermann, Kaj, Wagner, Christian, Buchrieser, Carmen, Emődy, Levente, Gottschalk, Gerhard, Hacker, Jörg, Dobrindt, Ulrich
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.08.2006; National Acad Sciences
• Subjects: Adaptability; Biological Evolution; Biological Sciences; Chromosomes, Bacterial - genetics; Deoxyribonucleic acid; DNA; DNA, Bacterial - genetics; E coli; Escherichia coli; Escherichia coli - classification; Escherichia coli - genetics; Escherichia coli - pathogenicity; Genes; Genetic research; Genome, Bacterial - genetics; Genomes; Genomics; Infections; Mice; Molecular Sequence Data; Multigene Family - genetics; Open reading frames; Operator regions; Operons; Pathogens; Phenotype; Strain; Virulence

Uropathogenic Escherichia coli (UPEC) strain 536 (O6:K15:H31) is one of the model organisms of extraintestinal pathogenic E. coli (ExPEC). To analyze this strain's genetic basis of urovirulence, we sequenced the entire genome and compared the data with the genome sequence of UPEC strain CFTO73...