A CaPful of mechanisms regulating the mitochondrial permeability transition

• Published in: Journal of molecular and cellular cardiology Vol. 46; no. 6; pp. 775 - 780
• Main Authors: Di Lisa, Fabio, Bernardi, Paolo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2009
• Subjects: Animals; Calcium; Calcium - metabolism; Cardiovascular; Cell death; Cyclophilins - metabolism; Cyclosporine - metabolism; Humans; Hydrogen-Ion Concentration; Mitochondria; Mitochondria - metabolism; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial Permeability Transition Pore; Models, Biological; Peptidyl-Prolyl Isomerase F; Permeability transition; Phosphate; Phosphates - metabolism; Phosphates - physiology; Reperfusion; Permeability transition; Mitochondria; Reperfusion; Calcium; Cell death; Phosphate

Despite the lack of its molecular identification, the mitochondrial permeability transition pore (PTP) is a fascinating subject because of its important role in cell death. This holds especially true for cardiovascular diseases and in particular for ischemia–reperfusion injury, where research on PTP...