Mitochondrial DNA-targeted therapy: A novel approach to combat cancer

• Published in: Cell insight Vol. 2; no. 4; p. 100113
• Main Authors: Lin, Yumeng, Yang, Bowen, Huang, Yibo, Zhang, You, Jiang, Yu, Ma, Longyun, Shen, Ying-Qiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2023; Elsevier
• Subjects: Cancer; Cancer therapy; Mitochondria; mtDNA; Review; Mitochondria; mtDNA; Cancer therapy; Cancer

Mitochondrial DNA (mtDNA) encodes proteins and RNAs that are essential for mitochondrial function and cellular homeostasis, and participates in important processes of cellular bioenergetics and metabolism. Alterations in mtDNA are associated with various diseases, especially cancers, and are conside...