A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China

• Published in: Virologica Sinica Vol. 32; no. 1; pp. 80 - 88
• Main Authors: Guo, Rong, Shen, Shu, Zhang, Yanfang, Shi, Junming, Su, Zhengyuan, Liu, Dan, Liu, Jinliang, Yang, Juan, Wang, Qiguo, Hu, Zhihong, Zhang, Yujiang, Deng, Fei
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2017; KeAi Publishing Communications Ltd
• Subjects: Animals; Animals, Newborn; Antigens; Antigens, Viral - analysis; basins; Biochemistry; Biomedical and Life Sciences; Biomedicine; China; Cluster Analysis; Crimean hemorrhagic fever; Crimean-Congo hemorrhagic fever orthonairovirus; disease prevention; Epidemics; Genotype; Genotypes; Hemorrhage; Hemorrhagic Fever Virus, Crimean-Congo - classification; Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification; Hemorrhagic Fever Virus, Crimean-Congo - physiology; Hyalomma asiaticum; Infections; Ixodidae - virology; Medical Microbiology; Mice, Inbred BALB C; Microbial Genetics and Genomics; Microbiology; mortality; neonates; Oncology; Outbreaks; Phylogeny; Research Article; Ribonucleic acid; RNA; RNA, Viral - genetics; Sequence Analysis, DNA; Sequence Homology; Viral Tropism; Virology; Virus Replication; viruses; China; Crimean-Congo hemorrhagic fever virus (CCHFV); phylogenetic analysis; newborn mice; genotype
• ISSN: 1674-0769; 1995-820X; 1995-820X
• DOI: 10.1007/s12250-016-3936-9

Crimean-Congo hemorrhagic fever virus （CCHFV） is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.