AP3B1 Has Type I Interferon-Independent Antiviral Function against SARS-CoV-2

• Published in: Viruses Vol. 16; no. 9; p. 1377
• Main Authors: Subramanian, Gayatri, Hage, Adam, Feldmann, Friederike, Chiramel, Abhilash I., McNally, Kristin L., Sturdevant, Gail L., Beare, Paul A., Best, Sonja M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.08.2024; MDPI
• Subjects: Adaptor Protein Complex 3 - genetics; Adaptor Protein Complex 3 - metabolism; Adaptor Protein Complex beta Subunits - genetics; Adaptor Protein Complex beta Subunits - metabolism; Animals; Antibodies; Antiviral activity; Antiviral agents; Antiviral drugs; antiviral proteins; AP3B1; biogenesis; Chlorocebus aethiops; Cloning; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - metabolism; COVID-19 - virology; Env protein; fluorescent antibody technique; genes; Health aspects; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunofluorescence; Immunoprecipitation; inflammation; Interferon; Interferon Type I - metabolism; Laboratories; Organelles; pathogenesis; Phosphatase; Plasmids; precipitin tests; Protein transport; Protein-protein interactions; Proteins; Proteomics; Pulmonary fibrosis; Replication; SARS-CoV-2; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; siRNA; Therapeutic targets; therapeutics; Vero Cells; Viral envelope proteins; Viral proteins; Virus Replication; Virus research; Viruses; United States; Austria; St Louis Missouri; United States > US; Vienna Austria; COVID-19; SARS-CoV-2; AP3B1; antiviral proteins

The unprecedented research effort associated with the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) included several extensive proteomic studies that identified host proteins that interact with individual viral gene products. However, in most cases, the consequences of th...