Low back pain patients with Modic type 1 changes exhibit distinct bacterial and non-bacterial subtypes

• Published in: Osteoarthritis and cartilage open Vol. 6; no. 1; p. 100434
• Main Authors: Heggli, I., Mengis, T., Laux, C.J., Opitz, L., Herger, N., Menghini, D., Schuepbach, R., Farshad-Amacker, N.A., Brunner, F., Fields, A.J., Farshad, M., Distler, O., Dudli, S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2024; Elsevier
• Subjects: Autoimmunity; Cutibacterium acnes; Etiology; Low back pain; Modic changes; ORIGINAL PAPER; Autoimmunity; Modic changes; Cutibacterium acnes; Etiology; Low back pain

Modic type 1 changes (MC1) are vertebral endplate bone marrow (BM) lesions observed on magnetic resonance images in sub-populations of chronic low back pain (CLBP) patients. The etiopathogenesis remains unknown and treatments that modify the underlying pathomechanisms do not exist. We hypothesized t...