Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron

• Published in: Cell reports (Cambridge) Vol. 42; no. 9; p. 113150
• Main Authors: Patel, Anamika, Kumar, Sanjeev, Lai, Lilin, Keen, Meredith, Valanparambil, Rajesh, Chakravarthy, Chennareddy, Laughlin, Zane, Frank, Filipp, Cheedarla, Narayanaiah, Verkerke, Hans P., Neish, Andrew S., Roback, John D., Davis, Carl W., Wrammert, Jens, Sharma, Amit, Ahmed, Rafi, Suthar, Mehul S., Murali-Krishna, Kaja, Chandele, Anmol, Ortlund, Eric
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.09.2023; Elsevier
• Subjects: Antibodies, Neutralizing; Antibodies, Viral; broadly neutralizing antibodies; COVID-19; CP: Microbiology; CP: Molecular biology; cryo-EM structure; Epitopes; Humans; Omicron; public antibodies; SARS-CoV-2; variants of concern; COVID-19; SARS-CoV-2; public antibodies; variants of concern; cryo-EM structure; CP: Microbiology; CP: Molecular biology; Omicron; broadly neutralizing antibodies

The pairing of antibody genes IGHV2-5/IGLV2-14 is established as a public immune response that potently cross-neutralizes SARS-CoV-2 variants, including Omicron, by targeting class-3/RBD-5 epitopes in the receptor binding domain (RBD). LY-CoV1404 (bebtelovimab) exemplifies this, displaying exception...