Progenitor/Stem Cells Give Rise to Liver Cancer Due to Aberrant TGF-β and IL-6 Signaling

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 7; pp. 2445 - 2450
• Main Authors: Tang, Yi, Kitisin, Krit, Jogunoori, Wilma, Li, Cuiling, Deng, Chu-Xia, Mueller, Susette C., Ressom, Habtom W., Rashid, Asif, He, Aiwu Ruth, Mendelson, Jonathan S., Jessup, John M., Shetty, Kirti, Zasloff, Michael, Mishra, Bibhuti, Reddy, E. P., Johnson, Lynt, Mishra, Lopa
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.02.2008; National Acad Sciences
• Subjects: Animals; Apoptosis; Biological Sciences; Calcium-Binding Proteins - deficiency; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cell growth; Cell Line; Cell lines; Cell Proliferation; Cell Separation; Cellular differentiation; Down-Regulation; Embryonic stem cells; foregut; Gene Expression Profiling; genes; Glycoproteins - deficiency; Glycoproteins - genetics; Glycoproteins - metabolism; Hepatocellular carcinoma; Hepatocytes; hepatoma; Humans; interleukin-6; Interleukin-6 - metabolism; Liver; Liver - cytology; Liver - metabolism; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Mice; Mice, Knockout; Pluripotent stem cells; Progenitor cells; Proteinase Inhibitory Proteins, Secretory; proteins; Signal Transduction; STAT3 Transcription Factor - metabolism; Stem cells; Stem Cells - metabolism; transforming growth factor beta; Transforming Growth Factor beta - metabolism

Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between specific signaling pathways in solid organ "cancer stem cells," such as those of the liver, remain elusive. We report that in regeneratin...