Progenitor/Stem Cells Give Rise to Liver Cancer Due to Aberrant TGF-β and IL-6 Signaling - Tang, Yi; Kitisin, Krit; Jogunoori, Wilma; Li, Cuiling; Deng, Chu-Xia; Mueller, Susette C.; Ressom, Habtom W.; Rashid, Asif; He, Aiwu Ruth; Mendelson, Jonathan S.; Jessup, John M.; Shetty, Kirti; et al. (Proceedings of the National Academy of Sciences - PNAS, 2008)
Keywords: Animals; Apoptosis; Biological Sciences; Calcium-Binding Proteins - deficiency; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cell growth; Cell Line; Cell lines; Cell Proliferation; Cell Separation; Cellular differentiation; Down-Regulation; Embryonic stem cells; foregut; Gene Expression Profiling; genes; Glycoproteins - deficiency; Glycoproteins - genetics; Glycoproteins - metabolism; Hepatocellular carcinoma; Hepatocytes; hepatoma; Humans; interleukin-6; Interleukin-6 - metabolism; Liver; Liver - cytology; Liver - metabolism; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Mice; Mice, Knockout; Pluripotent stem cells; Progenitor cells; Proteinase Inhibitory Proteins, Secretory; proteins; Signal Transduction; STAT3 Transcription Factor - metabolism; Stem cells; Stem Cells - metabolism; transforming growth factor beta; Transforming Growth Factor beta - metabolism