The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype

• Published in: Genes & diseases Vol. 10; no. 3; pp. 1114 - 1129
• Main Authors: Qin, Leilei, Yang, Jianye, Su, Xudong, Xilan li, Lei, Yiting, Dong, Lili, Chen, Hong, Chen, Cheng, Zhao, Chen, Zhang, Huan, Deng, Jun, Hu, Ning, Huang, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2023; Chongqing Medical University; KeAi Communications Co., Ltd
• Subjects: Apoptotic body; Extracellular vesicles; Full Length; Macrophage phenotype switch; MicroRNA-21; Osteoarthritis; Extracellular vesicles; MicroRNA-21; Macrophage phenotype switch; Apoptotic body; Osteoarthritis

Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs and increasing anti-inflammatory M2-Mφs can alleviate OA-related inflammation and promote cartilage repair. Apoptosis is a nat...