MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1

• Published in: Cellular physiology and biochemistry Vol. 46; no. 4; pp. 1439 - 1454
• Main Authors: Liu, Xiaoxiao, Xu, Yifeng, Deng, Yunfei, Li, Hongli
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.05.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: 3' Untranslated Regions; Actins - metabolism; Animals; Antagomirs - metabolism; Base Sequence; Cardiac fibrosis; Cardiac function; Cardiomyocytes; Cell adhesion & migration; Cell Differentiation - drug effects; Cell Movement - drug effects; Cell Proliferation; Cells, Cultured; Collagen Type I - metabolism; Collagen Type II - metabolism; Coronary vessels; Experiments; Fibroblasts; Fibroblasts - cytology; Fibroblasts - metabolism; Fibrosis; Gene expression; Growth factors; Heart attacks; Heart failure; Kinases; Male; MAP Kinase Kinase 1 - metabolism; MAP Kinase Kinase 2 - metabolism; Microrna-223; MicroRNAs; MicroRNAs - antagonists & inhibitors; MicroRNAs - genetics; MicroRNAs - metabolism; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Infarction - veterinary; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; Original Paper; Ostomy; p120 GTPase Activating Protein - antagonists & inhibitors; p120 GTPase Activating Protein - genetics; p120 GTPase Activating Protein - metabolism; Phosphorylation; Prevention; Proteins; Proto-Oncogene Proteins c-akt - metabolism; RASA1; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering - metabolism; Rodents; Sequence Alignment; Signal transduction; Transforming Growth Factor beta1 - pharmacology; Vimentin - metabolism; Grand Island; United States > US; Myocardial infarction; Microrna-223; Cardiac fibrosis; RASA1

Background/Aims: Percutaneous coronary intervention reduces acute myocardial infarction (MI)-induced mortality to a great extent, but effective treatments for MI-induced cardiac fibrosis and heart failure are still lacking. MicroRNAs (miRNAs) play a variety of roles in cells and have thus been inves...