Cycloartenyl trans-ferulate, a component of the bran byproduct of sake-brewing rice, inhibits mammalian DNA polymerase and suppresses inflammation

• Published in: Food chemistry Vol. 141; no. 2; pp. 1000 - 1007
• Main Authors: Mizushina, Yoshiyuki, Kuriyama, Isoko, Yamazaki, Asahi, Akashi, Takahiro, Yoshida, Hiromi
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.11.2013; Elsevier
• Subjects: analysis; Animals; Anti-inflammation; anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; bran; byproducts; Cattle; chemistry; correlation; Coumaric Acids; Coumaric Acids - chemistry; Coumaric Acids - isolation & purification; Coumaric Acids - pharmacology; Cycloartenyl trans-ferulate; DNA; DNA polymerase; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - analysis; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; drug therapy; ears; enzyme activity; Enzyme inhibitor; Enzyme Inhibitors; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Female; ferulic acid; Food toxicology; genetics; Humans; immunology; inflammation; Inflammation - drug therapy; Inflammation - immunology; isolation & purification; Medical sciences; metabolism; Mice; Mice, Inbred ICR; Nucleic Acid Synthesis Inhibitors; Oryza; Oryza - chemistry; Oryza sativa; pharmacology; Plant Extracts; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Rats; rice; sake; Sake-brewing rice bran; Seeds; Seeds - chemistry; Toxicology; Vitaceae; Waste Products; Waste Products - analysis; Wine; Wine - analysis; Enzyme inhibitor; Sake-brewing rice bran; DNA polymerase; Cycloartenyl trans-ferulate; Anti-inflammation; Inflammation; Vertebrata; Mammalia; DNA; Cereal; By product; Rice bran; Food; Rice

•Cycloartenyl trans-ferulate (CAF) was isolated from sake-brewing rice bran.•CAF inhibited the activity of mammalian DNA polymerases of A-, B-, and X-families.•The components of CAF, cycloartenol, and ferulic acid, had no inhibitory activity.•CAF had anti-inflammatory properties, unlike cycloartenol...