Repeated social defeat in female pigs does not induce neuroendocrine symptoms of depression, but behavioral adaptation

• Published in: Physiology & behavior Vol. 93; no. 3; pp. 453 - 460
• Main Authors: van der Staay, F.J, de Groot, J, Schuurman, T, Korte, S.M
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 27.02.2008; New York, NY Elsevier
• Subjects: Adaptation, Psychological - physiology; Adult and adolescent clinical studies; Animal model; animal-models; Animals; Behavior, Animal; Behavioral psychophysiology; Biological and medical sciences; confrontation; consequences; Cortisol; Depression; Dominance-Subordination; familiarity; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Glucocorticoid receptor; growing gilts; Hippocampus - metabolism; HPA axis; Hydrocortisone - metabolism; Medical sciences; medullary serotonergic system; Mineralocorticoid receptor; Mood disorders; piglets; posttraumatic-stress-disorder; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Receptors, Glucocorticoid - metabolism; Receptors, Mineralocorticoid - metabolism; Saliva - metabolism; salivary cortisol; Serotonin; Serotonin - metabolism; Social stress; Swine; Time Factors; unacquainted pigs; Animal model; Serotonin; Mineralocorticoid receptor; Glucocorticoid receptor; Depression; Cortisol; HPA axis; Social stress; Hypothalamohypophysoadrenal axis; Hydrocortisone; Glucocorticoid; Female; Behavior; Cortisol; Mineralocorticoid receptor; Glucocorticoid receptor; Serotonin; Ungulata; Adaptation; Mood disorder; Corticosteroid; Steroid hormone; Antiinflammatory agent; Stress; Pig; Symptomatology; Vertebrata; Mammalia; Animal; Adrenal hormone; Neurotransmitter; HPA axis; Animal model; Depression; Social stress; Artiodactyla

Abstract The aim of this study was to develop an animal model of major depression. Since two thirds of depressive patients are women, it is important to develop specific female animal models of depression. We therefore determined the consequences of chronic social defeat in individually housed prepu...