Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children

• Published in: Vaccine Vol. 44; p. 126573
• Main Authors: Anabe, Denise, Teräsjärvi, Johanna T., Barkoff, Alex-Mikael, Knuutila, Aapo, Pape, Bernd, van Gageldonk, Pieter, Buisman, Annemarie, Mertsola, Jussi, He, Qiushui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 12.01.2025; Elsevier Limited
• Subjects: Acellular vaccines; Adolescent; Adolescents; Adult; Adults; Age; Age groups; Aged; Allergy and Immunology; Antibodies; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antigens; blood serum; Child; Children; Chronology; Clinical trials; Cytokines; Cytokines - blood; Diphtheria; Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology; Female; fimbriae; Finland; Hemagglutinins; Humans; Immunity (Disease); Immunization, Secondary; Immunoglobulin A; Interleukin 10; Interleukin 13; Interleukin 17; Interleukin 2; Interleukin 5; Laboratories; Male; Middle Aged; Older people; Pertussis; Pertussis toxin; Pili; Population studies; secondary immunization; statistical models; Teenagers; Tetanus; Toxins; vaccination; Vaccines; Whooping cough; Whooping Cough - immunology; Whooping Cough - prevention & control; Young Adult; Young adults; γ-Interferon; Finland; Netherlands; United Kingdom > UK; United States > US; minDC; TT; rs; Cytokines; PT; Antibodies; Prn; aP; Pertussis; DT; Acellular vaccines; PTNA; wP; BERT; FHA; spearman correlation coefficient; r s; diphtheria toxoid; Booster Pertussis Vaccine Study; whole-cell pertussis vaccine; pertussis toxin; tetanus toxoid; pertactin; acellular pertussis vaccine; minimum detectable concentration; filamentous hemagglutinin; PT neutralizing antibodies

Despite extensive vaccinations, pertussis remains endemic and epidemic in multiple countries. The persistence of cases can be partly attributed to the significant individual variation in vaccine responses. This study evaluated the association of baseline cytokines (before booster vaccination) on ant...