An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice - Sheahan, Timothy P; Sims, Amy C; Zhou, Shuntai; Graham, Rachel L; Pruijssers, Andrea J; Agostini, Maria L; Leist, Sarah R; Schäfer, Alexandra; Dinnon, 3rd, Kenneth H; Stevens, Laura J; Chappell, James D; Lu, Xiaotao; et al. (Science translational medicine, 2020)
Keywords: Adenosine Monophosphate - administration & dosage; Adenosine Monophosphate - analogs & derivatives; Alanine - administration & dosage; Alanine - analogs & derivatives; Animals; Antibiotic Prophylaxis; Antiviral Agents - administration & dosage; Betacoronavirus - physiology; Cell Line; Coronavirus Infections - drug therapy; Coronavirus Infections - pathology; COVID-19; Cytidine - administration & dosage; Cytidine - analogs & derivatives; Disease Models, Animal; Drug Resistance, Viral; Humans; Hydroxylamines; Lung - pathology; Mice; Mice, Inbred C57BL; Middle East Respiratory Syndrome Coronavirus - physiology; Models, Molecular; Mutation - drug effects; Pandemics; Pneumonia, Viral - drug therapy; Pneumonia, Viral - pathology; Primary Cell Culture; Random Allocation; Respiratory System - cytology; Ribonucleosides - administration & dosage; RNA, Viral; RNA-Dependent RNA Polymerase - chemistry; RNA-Dependent RNA Polymerase - genetics; SARS-CoV-2; Virus Replication - drug effects