Vitamin C influences antioxidative, anti-inflammatory and wound healing markers in smokers’ gingival fibroblasts in vitro

• Published in: The Saudi dental journal Vol. 35; no. 4; pp. 337 - 344
• Main Authors: Alyami, Ruaa, Al Jasser, Reham, Alshehri, Fahad Ali, Alshibani, Nouf, Bin Hamdan, Sarah, Alyami, Riham Abdulaziz, Niazy, Abdurahman A.
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.05.2023; Elsevier; Springer
• Subjects: Anti-inflammatory; Antioxidant; Human gingival fibroblast; Original; RNA expression; Smoker; Vitamin C; Wound healing; RNA expression; Wound healing; Smoker; Human gingival fibroblast; Vitamin C; Antioxidant; Anti-inflammatory

Saudi Arabia has an overall smoking rate of 15.9%. The link between smoking and periodontal disease has been studied extensively. It is possible for human gingival fibroblasts to accumulate nicotine intracellularly over a period of four hours. Additionally, unmetabolized nicotine is released into th...