Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma in the Multiethnic Cohort Study

•We evaluated serum PFAS and RCC risk in a racially and ethnically diverse cohort.•Concentrations of several PFAS differed by race and ethnicity (e.g., higher PFOS and PFNA in African American vs. White participants)•PFOA was suggestively associated with increased RCC risk among White participants.•...

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Published inEnvironment international Vol. 180; p. 108197
Main Authors Rhee, Jongeun, Chang, Vicky C., Cheng, Iona, Calafat, Antonia M., Botelho, Julianne Cook, Shearer, Joseph J., Sampson, Joshua N., Setiawan, Veronica Wendy, Wilkens, Lynne R., Silverman, Debra T., Purdue, Mark P., Hofmann, Jonathan N.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.10.2023
Elsevier
Subjects
Adult
Alkanesulfonic Acids
Caprylates
Carcinoma, Renal Cell - epidemiology
Case-Control Studies
Cohort Studies
Environmental Pollutants
Female
Fluorocarbons
Humans
Kidney cancer
Kidney Neoplasms - epidemiology
Male
Multiethnic cohort
Per- and polyfluoroalkyl substances (PFAS)
Perfluorononanoate (PFNA)
Perfluorooctanoate (PFOA)
Renal cell carcinoma
Perfluorononanoate (PFNA)
Sm-PFOS
MeFOSAA
PFNA
n-PFOS
PFAS
PLCO
QC
n-PFOA
Renal cell carcinoma
Per- and polyfluoroalkyl substances (PFAS)
PFDA
NHPI
Sb-PFOA
ICD-O-3
BMI
eGFR
LOD
EtFOSAA
PFHxS
MEC
PFUnDA
IARC
Cis
PFOA
Perfluorooctanoate (PFOA)
Multiethnic cohort
ORs
NCI
FOSA
Kidney cancer
NHANES
PFOS
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Abstract •We evaluated serum PFAS and RCC risk in a racially and ethnically diverse cohort.•Concentrations of several PFAS differed by race and ethnicity (e.g., higher PFOS and PFNA in African American vs. White participants)•PFOA was suggestively associated with increased RCC risk among White participants.•We found a strong positive PFNA-RCC association among African American participants. Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993–2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study. We measured pre-diagnostic serum concentrations of nine PFAS among 428 RCC cases and 428 individually matched controls. We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for risk of RCC in relation to each PFAS using conditional logistic regression, adjusting for RCC risk factors and other PFAS. PFOA was not associated with RCC risk overall [doubling in serum concentration, ORcontinuous = 0.89 (95 %CI = 0.67, 1.18)]. However, we observed suggestive positive associations among White participants [2.12 (0.87, 5.18)] and among participants who had blood drawn before 2002 [1.49 (0.77, 2.87)]. Furthermore, higher perfluorononanoate (PFNA) concentration was associated with increased risk of RCC overall [fourth vs. first quartile, OR = 1.84 (0.97, 3.50), Ptrend = 0.04; ORcontinuous = 1.29 (0.97, 1.71)], with the strongest association observed among African American participants [ORcontinuous = 3.69 (1.33, 10.25)], followed by Native Hawaiian [2.24 (0.70, 7.19)] and White [1.98 (0.92, 4.25)] participants. Most other PFAS were not associated with RCC. While PFOA was not associated with RCC risk overall in this racially and ethnically diverse population, the positive associations observed among White participants and those with sera collected before 2002 are consistent with previous PLCO findings. Our study also provided new evidence of a positive association between PFNA and RCC risk that was strongest in African American participants. These findings highlight the need for additional epidemiologic research investigating PFAS exposures and RCC in large racially and ethnically diverse populations.
AbstractList Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993-2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study. We measured pre-diagnostic serum concentrations of nine PFAS among 428 RCC cases and 428 individually matched controls. We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for risk of RCC in relation to each PFAS using conditional logistic regression, adjusting for RCC risk factors and other PFAS. PFOA was not associated with RCC risk overall [doubling in serum concentration, ORcontinuous = 0.89 (95 %CI = 0.67, 1.18)]. However, we observed suggestive positive associations among White participants [2.12 (0.87, 5.18)] and among participants who had blood drawn before 2002 [1.49 (0.77, 2.87)]. Furthermore, higher perfluorononanoate (PFNA) concentration was associated with increased risk of RCC overall [fourth vs. first quartile, OR = 1.84 (0.97, 3.50), Ptrend = 0.04; ORcontinuous = 1.29 (0.97, 1.71)], with the strongest association observed among African American participants [ORcontinuous = 3.69 (1.33, 10.25)], followed by Native Hawaiian [2.24 (0.70, 7.19)] and White [1.98 (0.92, 4.25)] participants. Most other PFAS were not associated with RCC. While PFOA was not associated with RCC risk overall in this racially and ethnically diverse population, the positive associations observed among White participants and those with sera collected before 2002 are consistent with previous PLCO findings. Our study also provided new evidence of a positive association between PFNA and RCC risk that was strongest in African American participants. These findings highlight the need for additional epidemiologic research investigating PFAS exposures and RCC in large racially and ethnically diverse populations.
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993–2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study. We measured pre-diagnostic serum concentrations of nine PFAS among 428 rCc cases and 428 individually matched controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for risk of RCC in relation to each PFAS using conditional logistic regression, adjusting for RCC risk factors and other PFAS. PFOA was not associated with RCC risk overall [doubling in serum concentration, OR continuous =0.89 (95%CI=0.67,1.18)]. However, we observed suggestive positive associations among White participants [2.12 (0.87,5.18)] and among participants who had blood drawn before 2002 [1.49 (0.77,2.87)]. Furthermore, higher perfluorononanoate (PFNA) concentration was associated with increased risk of RCC overall [fourth vs. first quartile, OR=1.84 (0.97,3.50), P trend =0.04; OR continuous =1.29 (0.97,1.71)], with the strongest association observed among African American participants [OR continuous =3.69 (1.33,10.25)], followed by Native Hawaiian [2.24 (0.70,7.19)] and White [1.98 (0.92,4.25)] participants. Most other PFAS were not associated with RCC. While PFOA was not associated with RCC risk overall in this racially and ethnically diverse population, the positive associations observed among White participants and those with sera collected before 2002 are consistent with previous PLCO findings. Our study also provided new evidence of a positive association between PFNA and RCC risk that was strongest in African American participants. These findings highlight the need for additional epidemiologic research investigating PFAS exposures and RCC in large racially and ethnically diverse populations.
•We evaluated serum PFAS and RCC risk in a racially and ethnically diverse cohort.•Concentrations of several PFAS differed by race and ethnicity (e.g., higher PFOS and PFNA in African American vs. White participants)•PFOA was suggestively associated with increased RCC risk among White participants.•We found a strong positive PFNA-RCC association among African American participants. Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993–2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study. We measured pre-diagnostic serum concentrations of nine PFAS among 428 RCC cases and 428 individually matched controls. We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for risk of RCC in relation to each PFAS using conditional logistic regression, adjusting for RCC risk factors and other PFAS. PFOA was not associated with RCC risk overall [doubling in serum concentration, ORcontinuous = 0.89 (95 %CI = 0.67, 1.18)]. However, we observed suggestive positive associations among White participants [2.12 (0.87, 5.18)] and among participants who had blood drawn before 2002 [1.49 (0.77, 2.87)]. Furthermore, higher perfluorononanoate (PFNA) concentration was associated with increased risk of RCC overall [fourth vs. first quartile, OR = 1.84 (0.97, 3.50), Ptrend = 0.04; ORcontinuous = 1.29 (0.97, 1.71)], with the strongest association observed among African American participants [ORcontinuous = 3.69 (1.33, 10.25)], followed by Native Hawaiian [2.24 (0.70, 7.19)] and White [1.98 (0.92, 4.25)] participants. Most other PFAS were not associated with RCC. While PFOA was not associated with RCC risk overall in this racially and ethnically diverse population, the positive associations observed among White participants and those with sera collected before 2002 are consistent with previous PLCO findings. Our study also provided new evidence of a positive association between PFNA and RCC risk that was strongest in African American participants. These findings highlight the need for additional epidemiologic research investigating PFAS exposures and RCC in large racially and ethnically diverse populations.
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993–2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study. We measured pre-diagnostic serum concentrations of nine PFAS among 428 RCC cases and 428 individually matched controls. We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for risk of RCC in relation to each PFAS using conditional logistic regression, adjusting for RCC risk factors and other PFAS. PFOA was not associated with RCC risk overall [doubling in serum concentration, ORcontinuous = 0.89 (95 %CI = 0.67, 1.18)]. However, we observed suggestive positive associations among White participants [2.12 (0.87, 5.18)] and among participants who had blood drawn before 2002 [1.49 (0.77, 2.87)]. Furthermore, higher perfluorononanoate (PFNA) concentration was associated with increased risk of RCC overall [fourth vs. first quartile, OR = 1.84 (0.97, 3.50), Ptrend = 0.04; ORcontinuous = 1.29 (0.97, 1.71)], with the strongest association observed among African American participants [ORcontinuous = 3.69 (1.33, 10.25)], followed by Native Hawaiian [2.24 (0.70, 7.19)] and White [1.98 (0.92, 4.25)] participants. Most other PFAS were not associated with RCC. While PFOA was not associated with RCC risk overall in this racially and ethnically diverse population, the positive associations observed among White participants and those with sera collected before 2002 are consistent with previous PLCO findings. Our study also provided new evidence of a positive association between PFNA and RCC risk that was strongest in African American participants. These findings highlight the need for additional epidemiologic research investigating PFAS exposures and RCC in large racially and ethnically diverse populations.
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993-2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study. We measured pre-diagnostic serum concentrations of nine PFAS among 428 RCC cases and 428 individually matched controls. We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for risk of RCC in relation to each PFAS using conditional logistic regression, adjusting for RCC risk factors and other PFAS. PFOA was not associated with RCC risk overall [doubling in serum concentration, OR  = 0.89 (95 %CI = 0.67, 1.18)]. However, we observed suggestive positive associations among White participants [2.12 (0.87, 5.18)] and among participants who had blood drawn before 2002 [1.49 (0.77, 2.87)]. Furthermore, higher perfluorononanoate (PFNA) concentration was associated with increased risk of RCC overall [fourth vs. first quartile, OR = 1.84 (0.97, 3.50), P  = 0.04; OR  = 1.29 (0.97, 1.71)], with the strongest association observed among African American participants [OR  = 3.69 (1.33, 10.25)], followed by Native Hawaiian [2.24 (0.70, 7.19)] and White [1.98 (0.92, 4.25)] participants. Most other PFAS were not associated with RCC. While PFOA was not associated with RCC risk overall in this racially and ethnically diverse population, the positive associations observed among White participants and those with sera collected before 2002 are consistent with previous PLCO findings. Our study also provided new evidence of a positive association between PFNA and RCC risk that was strongest in African American participants. These findings highlight the need for additional epidemiologic research investigating PFAS exposures and RCC in large racially and ethnically diverse populations.
ArticleNumber 108197
Author Rhee, Jongeun
Shearer, Joseph J.
Chang, Vicky C.
Sampson, Joshua N.
Setiawan, Veronica Wendy
Silverman, Debra T.
Purdue, Mark P.
Cheng, Iona
Botelho, Julianne Cook
Hofmann, Jonathan N.
Calafat, Antonia M.
Wilkens, Lynne R.
AuthorAffiliation 2 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
5 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
4 Heart Disease Phenomics Laboratory, Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
1 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
6 Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, University of Southern California, CA, USA
3 Organic Analytical Toxicology Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
7 Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawa
AuthorAffiliation_xml – name: 6 Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, University of Southern California, CA, USA
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– name: 7 Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, Honolulu, Hawaii, USA
– name: 5 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
– name: 2 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
– name: 4 Heart Disease Phenomics Laboratory, Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37741007$$D View this record in MEDLINE/PubMed
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IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Perfluorononanoate (PFNA)
Sm-PFOS
MeFOSAA
PFNA
n-PFOS
PFAS
PLCO
QC
n-PFOA
Renal cell carcinoma
Per- and polyfluoroalkyl substances (PFAS)
PFDA
NHPI
Sb-PFOA
ICD-O-3
BMI
eGFR
LOD
EtFOSAA
PFHxS
MEC
PFUnDA
IARC
Cis
PFOA
Perfluorooctanoate (PFOA)
Multiethnic cohort
ORs
NCI
FOSA
Kidney cancer
NHANES
PFOS
Language English
License This is an open access article under the CC BY-NC-ND license.
Published by Elsevier Ltd.
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content type line 23
Co-first authors.
Co-senior authors.
ORCID 0000-0002-9796-7482
0000-0001-8894-0301
0000-0002-1443-7428
0000-0003-1873-9359
0000-0003-2875-3365
0000-0002-1043-5812
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  year: 2023
  text: 2023-10-01
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PublicationTitle Environment international
PublicationTitleAlternate Environ Int
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Elsevier
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Snippet •We evaluated serum PFAS and RCC risk in a racially and ethnically diverse cohort.•Concentrations of several PFAS differed by race and ethnicity (e.g., higher...
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously...
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StartPage 108197
SubjectTerms Adult
Alkanesulfonic Acids
Caprylates
Carcinoma, Renal Cell - epidemiology
Case-Control Studies
Cohort Studies
Environmental Pollutants
Female
Fluorocarbons
Humans
Kidney cancer
Kidney Neoplasms - epidemiology
Male
Multiethnic cohort
Per- and polyfluoroalkyl substances (PFAS)
Perfluorononanoate (PFNA)
Perfluorooctanoate (PFOA)
Renal cell carcinoma
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Title Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma in the Multiethnic Cohort Study
URI https://dx.doi.org/10.1016/j.envint.2023.108197
https://www.ncbi.nlm.nih.gov/pubmed/37741007
https://search.proquest.com/docview/2868124633
https://pubmed.ncbi.nlm.nih.gov/PMC11093414
https://doaj.org/article/97243b5973894ceb85ba2346703d7b2a
Volume 180
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