Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

• Published in: The Lancet (British edition) Vol. 376; no. 9756; pp. 1916 - 1922
• Main Authors: Athyros, Vasilios G, Tziomalos, Konstantinos, Gossios, Thomas D, Griva, Theodora, Anagnostis, Panagiotis, Kargiotis, Konstantinos, Pagourelias, Efstathios D, Theocharidou, Eleni, Karagiannis, Asterios, Mikhailidis, Dimitri P
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 04.12.2010; Elsevier; Elsevier Limited
• Subjects: Aged; Atherosclerosis; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Coronary Disease - complications; Coronary Disease - drug therapy; Coronary heart disease; Data collection; Diabetes; Fatty Liver - blood; Fatty Liver - complications; Fatty Liver - drug therapy; Female; General aspects; Greece; Heart; Heart failure; Hospitals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Insulin resistance; Internal Medicine; Liver; Liver Function Tests; Male; Medical sciences; Middle Aged; Mortality; Non-alcoholic Fatty Liver Disease; Prospective Studies; Recurrence; Regression analysis; Risk Reduction Behavior; Statins; Time Factors; Treatment Outcome; Greece; Europe; Human; Evaluation; Digestive system; Enzyme; Toxicity; Treatment efficiency; Liver; Enzyme inhibitor; Exploration; Patient; Cardiovascular disease; Statin derivative; Hypocholesterolemic agent; Coronary heart disease; Long term; Medicine; Treatment; HMG-CoA reductase inhibitor; Atorvastatin; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Safety; Greek; Antilipemic agent

Long-term statin treatment reduces the frequency of cardiovascular events, but safety and efficacy in patients with abnormal liver tests is unclear. We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and Coronary Heart Dise...