Expression of ephrinA5 during development and potential involvement in the guidance of the mesostriatal pathway

• Published in: Experimental neurology Vol. 219; no. 2; pp. 466 - 480
• Main Authors: Deschamps, C., Faideau, M., Jaber, M., Gaillard, A., Prestoz, L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.10.2009; Elsevier
• Subjects: Animals; Animals, Newborn; Axon guidance; Axons - drug effects; Axons - physiology; Biological and medical sciences; Cells, Cultured; Corpus Striatum - cytology; Development. Senescence. Regeneration. Transplantation; Dopamine; Embryo, Mammalian; Ephrin; Ephrin-A5 - deficiency; Ephrin-A5 - genetics; Ephrin-A5 - metabolism; Ephrin-A5 - pharmacology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Developmental; In Vitro Techniques; Life Sciences; Medical sciences; Mesencephalon - cytology; Mice; Mice, Inbred C57BL; Mice, Knockout; Midbrain; Neural Pathways - physiology; Neurobiology; Neurology; Neurons - cytology; Neurons - physiology; Neurons and Cognition; Receptors, Eph Family - genetics; Receptors, Eph Family - metabolism; RNA, Messenger - metabolism; Tyrosine 3-Monooxygenase - metabolism; Tyrosine hydroxylase; Vertebrates: nervous system and sense organs; Midbrain; Tyrosine hydroxylase; Ephrin; Dopamine; Axon guidance; Nervous system diseases; Enzyme; Central nervous system; Axon; Catecholamine; Tyrosine 3-monooxygenase; Guidance; Neurotransmitter; Oxidoreductases

Identifying guidance cues that direct axon growth to their final connections during development is of crucial interest if we aim to repair circuits damaged in adulthood following neurodegenerative disorders or common traumatic injuries. In this work, we set out to determine the ephrinA5 guidance mol...