Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation

• Published in: Frontiers in cell and developmental biology Vol. 8; p. 543066
• Main Authors: Streletskaia, Alena Y., Senichkin, Viacheslav V., Prikazchikova, Tatiana A., Zatsepin, Timofei S., Zhivotovsky, Boris, Kopeina, Gelina S.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 25.09.2020
• Subjects: apoptosis; BH3-mimetics; Cell and Developmental Biology; cell cycle; Mcl-1; Medicin och hälsovetenskap; splicing switch

As an important regulator of apoptosis, Mcl-1 protein, a member of the Bcl-2 family, represents an attractive target for cancer treatment. The recent development of novel small molecule compounds has allowed Mcl-1-inhibitory therapy to proceed to clinical trials in cancer treatment. However, the pos...