The p47 GTPases Igtp and Irgb10 Map to the Chlamydia Trachomatis Susceptibility Locus Ctrq-3 and Mediate Cellular Resistance in Mice

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 38; pp. 14092 - 14097
• Main Authors: Bernstein-Hanley, Isaac, Coers, Jörn, Balsara, Zarine R., Taylor, Gregory A., Starnbach, Michael N., Dietrich, William F.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.09.2006; National Acad Sciences
• Subjects: Amino Acid Sequence; Animals; Biological Sciences; Cells, Cultured; Chlamydia; Chlamydia Infections - genetics; Chlamydia Infections - immunology; Chlamydia trachomatis; Chlamydia trachomatis - immunology; Chromosome Mapping; Chromosomes; Chromosomes, Mammalian; Disease Susceptibility; DNA; Fibroblasts; Fibroblasts - cytology; Fibroblasts - physiology; Genetics; Genomics; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Humans; Immunity (Disease); Infections; Interferon; Interferon-gamma - metabolism; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Models, Genetic; Molecular Sequence Data; Pathogens; Phenotypes; Quantitative trait loci; Rodents

Infections caused by the bacteria Chlamydia trachomatis contribute to diverse pathologies in a variety of human populations. We previously used a systemic model of C trachomatis infection in mice to map three quantitative trait loci that influence in vivo susceptibility differences between the C57BL...